There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 5622 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 5605 | - |
dc.citation.title | Nucleic Acids Research | - |
dc.citation.volume | 49 | - |
dc.contributor.author | Ju, Min Kyung | - |
dc.contributor.author | Shin, Kyeong Jin | - |
dc.contributor.author | Lee, Joo Rak | - |
dc.contributor.author | Khim, Keon Woo | - |
dc.contributor.author | Lee, Eun A | - |
dc.contributor.author | Ra, Jae Sun | - |
dc.contributor.author | Kim, Byung-Gyu | - |
dc.contributor.author | Jo, Han-seul | - |
dc.contributor.author | Yoon, Jong Hyuk | - |
dc.contributor.author | Kim, Tae Moon | - |
dc.contributor.author | Myung, Kyungjae | - |
dc.contributor.author | Kim, Hongtae | - |
dc.contributor.author | Choi, Jang Hyun | - |
dc.contributor.author | Chae, Young Chan | - |
dc.date.accessioned | 2023-12-21T15:45:10Z | - |
dc.date.available | 2023-12-21T15:45:10Z | - |
dc.date.created | 2021-05-10 | - |
dc.date.issued | 2021-06 | - |
dc.description.abstract | Proper activation of DNA repair pathways in response to DNA replication stress is critical for maintaining genomic integrity. Due to the complex nature of the replication fork (RF), problems at the RF require multiple proteins, some of which remain unidentified, for resolution. In this study, we identified the N-methyl-D-aspartate receptor synaptonuclear signaling and neuronal migration factor (NSMF) as a key replication stress response factor that is important for ataxia telangiectasia and Rad3-related protein (ATR) activation. NSMF localizes rapidly to stalled RFs and acts as a scaffold to modulate replication protein A (RPA) complex formation with cell division cycle 5-like (CDC5L) and ATR/ATR-interacting protein (ATRIP). Depletion of NSMF compromised phosphorylation and ubiquitination of RPA2 and the ATR signaling cascade, resulting in genomic instability at RFs under DNA replication stress. Consistently, NSMF knockout mice exhibited increased genomic instability and hypersensitivity to genotoxic stress. NSMF deficiency in human and mouse cells also caused increased chromosomal instability. Collectively, these findings demonstrate that NSMF regulates the ATR pathway and the replication stress response network for genome maintenance and cell survival. | - |
dc.identifier.bibliographicCitation | Nucleic Acids Research, v.49, no.10, pp.5605 - 5622 | - |
dc.identifier.doi | 10.1093/nar/gkab311 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.scopusid | 2-s2.0-85108123883 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/52848 | - |
dc.identifier.url | https://academic.oup.com/nar/article/49/10/5605/6272432 | - |
dc.identifier.wosid | 000671549500018 | - |
dc.language | 영어 | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | NSMF promotes the replication stress-induced DNA damage response for genome maintenance | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | ATR ACTIVATIONPROTEIN-ARPA-SSDNAGENEPHOSPHORYLATIONINSTABILITYPHENOTYPESKINASEMODELNELF | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.