BROWSE

Related Researcher

Author's Photo

Hong, Sung You
Synthetic Organic Chemistry Laboratory
Research Interests
  • Synthetic organic chemistry, transition metals, oxidation state

ITEM VIEW & DOWNLOAD

Late-Stage F-18/F-19 Isotopic Exchange for the Synthesis of F-18-Labeled Sulfamoyl Fluorides

Cited 0 times inthomson ciCited 0 times inthomson ci
Title
Late-Stage F-18/F-19 Isotopic Exchange for the Synthesis of F-18-Labeled Sulfamoyl Fluorides
Author
Jeon, Min HoKwon, Young-DoKim, Min PyeongTorres, Gianluca BartoliniSeo, Jeong KonSon, JeongminRyu, Young HoonHong, Sung YouChun, Joong-Hyun
Issue Date
2021-04
Publisher
AMER CHEMICAL SOC
Citation
ORGANIC LETTERS, v.23, no.7, pp.2766 - 2771
Abstract
Synthesis of sulfamoyl [F-18]fluorides has been a challenging topic owing to the inefficient nucleophilic radiofluorination of sulfamoyl derivatives. Herein, we report an F-18/F-19 isotopic exchange approach to synthesize various sulfamoyl [F-18]fluorides, otherwise inaccessible via direct synthesis from amines, with high radiochemical yields up to 97% (30 examples). This late-stage labeling protocol offers an efficient route to yield functionalized molecules by diversifying the chemical library possessing sulfamoyl functionalities through nucleophilic F-18 incorporation within nitrogen-containing sulfur(VI) frameworks.
URI
https://scholarworks.unist.ac.kr/handle/201301/52649
URL
https://pubs.acs.org/doi/10.1021/acs.orglett.1c00671
DOI
10.1021/acs.orglett.1c00671
ISSN
1523-7060
Appears in Collections:
CHM_Journal Papers
UCRF_Journal Papers
Files in This Item:
There are no files associated with this item.

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU