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Hong, Sung You
Synthetic Organic Chemistry Laboratory
Research Interests
  • Synthetic organic chemistry, transition metals, oxidation state

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Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging

Cited 109 times inthomson ciCited 91 times inthomson ci
Title
Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging
Author
Hong, Sung YouTobias, GerardAl-Jamal, Khuloud T.Ballesteros, BelenAli-Boucetta, HaneneLozano-Perez, SergioNellist, Peter D.Sim, Robert B.Finucane, CiaraMather, Stephen J.Green, Malcolm L. H.Kostarelos, KostasDavis, Benjamin G.
Issue Date
2010-06
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE MATERIALS, v.9, no.6, pp.485 - 490
Abstract
Functionalization of nanomaterials for precise biomedical function is an emerging trend in nanotechnology. Carbon nanotubes are attractive as multifunctional carrier systems because payload can be encapsulated in internal space whilst outer surfaces can be chemically modified. Yet, despite potential as drug delivery systems and radiotracers, such filled-and-functionalized carbon nanotubes have not been previously investigated in vivo. Here we report covalent functionalization of radionuclide-filled single-walled carbon nanotubes and their use as radioprobes. Metal halides, including Na 125 I, were sealed inside single-walled carbon nanotubes to create high-density radioemitting crystals and then surfaces of these filled-sealed nanotubes were covalently modified with biantennary carbohydrates, improving dispersibility and biocompatibility. Intravenous administration of Na 125 I-filled glyco-single-walled carbon nanotubes in mice was tracked in vivo using single-photon emission computed tomography. Specific tissue accumulation (here lung) coupled with high in vivo stability prevented leakage of radionuclide to high-affinity organs (thyroid/stomach) or excretion, and resulted in ultrasensitive imaging and delivery of unprecedented radiodose density. Nanoencapsulation of iodide within single-walled carbon nanotubes enabled its biodistribution to be completely redirected from tissue with innate affinity (thyroid) to lung. Surface functionalization of 125 I-filled single-walled carbon nanotubes offers versatility towards modulation of biodistribution of these radioemitting crystals in a manner determined by the capsule that delivers them. We envisage that organ-specific therapeutics and diagnostics can be developed on the basis of the nanocapsule model described here.
URI
https://scholarworks.unist.ac.kr/handle/201301/5245
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77954570797
DOI
10.1038/NMAT2766
ISSN
1476-1122
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CHM_Journal Papers
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