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Suh, Pann-Ghill
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Interleukin-6-induced tyrosine phosphorylation of phospholipase C-gamma1 in PC12 cells

Author(s)
Lee, YHBae, SSSeo, JKChoi, IRyu, SHSuh, Pann-Ghill
Issued Date
1998-06-24
URI
https://scholarworks.unist.ac.kr/handle/201301/52339
Citation
Asian-Pacific Society for Neurochemistry 4th Meeting
Abstract
Phospholipase C (PLC)-gamma1 plays a pivotal role in the signal transduction pathway mediated by growth factors. In this study, we found that neurite outgrowth of pheochromocytoma (PC12) cells was significantly induced by interleukin-6 (IL-6). Stimulation of PC12 cells with IL-6 led to tyrosine phosphorylation of PLC-gamma1 in a dose- and time-dependent manner. IL-6 stimulation also increased the hydrolysis of phosphatidylinositol 4,5-bisphosphate. Accumulation of total inositol phosphate as well as tyrosine phosphorylation of PLC-gamma1 was inhibited by the pretreatment of protein kinase inhibitors such as genistein and staurosporine. These results suggest that PLC-gamma1 may be involved in the signal transduction pathway of IL-6-induced PC12 cell differentiation
Publisher
J. Neurochem. Suppl. 2, S38D,

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