Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 651 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 642 | - |
dc.citation.title | MOLECULAR METABOLISM | - |
dc.citation.volume | 3 | - |
dc.contributor.author | Kim, Min | - |
dc.contributor.author | Neinast, Michael D. | - |
dc.contributor.author | Frank, Aaron P. | - |
dc.contributor.author | Sun, Kai | - |
dc.contributor.author | Park, Jiyoung | - |
dc.contributor.author | Zehr, Jordan A. | - |
dc.contributor.author | Vishvanath, Lavanya | - |
dc.contributor.author | Morselli, Eugenia | - |
dc.contributor.author | Amelotte, Mason | - |
dc.contributor.author | Palmer, Biff F. | - |
dc.contributor.author | Gupta, Rana K. | - |
dc.contributor.author | Scherer, Philipp E. | - |
dc.contributor.author | Clegg, Deborah J. | - |
dc.date.accessioned | 2023-12-22T02:13:49Z | - |
dc.date.available | 2023-12-22T02:13:49Z | - |
dc.date.created | 2014-07-09 | - |
dc.date.issued | 2014-09 | - |
dc.description.abstract | Hypoxia Inducible Factor 1 (HIF-1) promotes fibrosis and inflammation in adipose tissues, while estrogens and Estrogen Receptor α (ERα) have the opposite effect. Here we identify an Estrogen Response Element (ERE) in the promoter of Phd3, which is a negative regulatory enzyme of HIF-1, and we demonstrate HIF-1α is ubiquitinated following 17-β estradiol (E2)/ERα mediated Phd3 transcription. Manipulating ERα in vivo increases Phd3 transcription and reduces HIF-1 activity, while addition of PHD3 ameliorates adipose tissue fibrosis and inflammation. Our findings outline a novel regulatory relationship between E2/ERα, PHD3 and HIF-1 in adipose tissues, providing a mechanistic explanation for the protective effect of E2/ERα in adipose tissue. | - |
dc.identifier.bibliographicCitation | MOLECULAR METABOLISM, v.3, no.6, pp.642 - 651 | - |
dc.identifier.doi | 10.1016/j.molmet.2014.05.007 | - |
dc.identifier.issn | 2212-8778 | - |
dc.identifier.scopusid | 2-s2.0-84906239136 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/5171 | - |
dc.identifier.wosid | 000209638500006 | - |
dc.language | 영어 | - |
dc.publisher | Elsevier GmbH | - |
dc.title | ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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