Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.number | 1 | - |
dc.citation.startPage | 450 | - |
dc.citation.title | BMC GENOMICS | - |
dc.citation.volume | 15 | - |
dc.contributor.author | Chi, Sang-Mun | - |
dc.contributor.author | Seo, Young Kyo | - |
dc.contributor.author | Park, Young-Kyu | - |
dc.contributor.author | Yoon, Sora | - |
dc.contributor.author | Park, Chan Young | - |
dc.contributor.author | Kim, Yong Sung | - |
dc.contributor.author | Kim, Seon-Young | - |
dc.contributor.author | Nam, Dougu | - |
dc.date.accessioned | 2023-12-22T02:38:42Z | - |
dc.date.available | 2023-12-22T02:38:42Z | - |
dc.date.created | 2014-07-01 | - |
dc.date.issued | 2014-06 | - |
dc.description.abstract | Background: Genome-wide expression profiles reflect the transcriptional networks specific to the given cell context. However, most statistical models try to estimate the average connectivity of the networks from a collection of gene expression data, and are unable to characterize the context-specific transcriptional regulations. We propose an approach for mining context-specific transcription networks from a large collection of gene expression fold-change profiles and composite gene-set information.Results: Using a composite gene-set analysis method, we combine the information of transcription factor binding sites, Gene Ontology or pathway gene sets and gene expression fold-change profiles for a variety of cell conditions. We then collected all the significant patterns and constructed a database of context-specific transcription networks for human (REGNET). As a result, context-specific roles of transcription factors as well as their functional targets are readily explored. To validate the approach, nine predicted targets of E2F1 in HeLa cells were tested using chromatin immunoprecipitation assay. Among them, five (Gadd45b, Dusp6, Mll5, Bmp2 and E2f3) were successfully bound by E2F1. c-JUN and the EMT transcription networks were also validated from literature.Conclusions: REGNET is a useful tool for exploring the ternary relationships among the transcription factors, their functional targets and the corresponding cell conditions. It is able to provide useful clues for novel cell-specific transcriptional regulations. The REGNET database is available at http://mgrc.kribb.re.kr/regnet. | - |
dc.identifier.bibliographicCitation | BMC GENOMICS, v.15, no.1, pp.450 | - |
dc.identifier.doi | 10.1186/1471-2164-15-450 | - |
dc.identifier.issn | 1471-2164 | - |
dc.identifier.scopusid | 2-s2.0-84902549053 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/5110 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84902549053 | - |
dc.identifier.wosid | 000338261900001 | - |
dc.language | 영어 | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.title | REGNET: Mining context-specific human transcription networks using composite genomic information | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology; Genetics & Heredity | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology; Genetics & Heredity | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.