BBB biomimetic system for isolation of novel BBB shuttle molecules

Abstract

Microfluidic biomimetic system represents a new avenue in a range of area in preclinical precision drug validation and new drug discovery. A patient's own cells could be adapted with induced pluripotent stem cell (iPSC) techniques to develop biomimetic system which emulates individual organ-level function. Here, I will discuss recent research related to precision medicine including identification of functional peptide for efficient drug delivery, and target-based drug screening enabled by personalized BBB (blood-brain barrier)-on-a-chip, as well as the importance of biological point of view in realizing the full potential of this t