SIFamide and SIFamide receptor define a novel neuropeptide signaling to promote sleep in Drosophila

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Title
SIFamide and SIFamide receptor define a novel neuropeptide signaling to promote sleep in Drosophila
Author
Park, SangjinSonn, Jun YoungOh, YangkyunLim, ChunghunChoe, Joonho
Issue Date
2014-04
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Citation
MOLECULES AND CELLS, v.37, no.4, pp.295 - 301
Abstract
SIFamide receptor (SIFR) is a Drosophila G protein-coupled receptor for the neuropeptide SIFamide (SIFa). Although the sequence and spatial expression of SIFa are evolutionarily conserved among insect species, the physiological function of SIFa/SIFR signaling remains elusive. Here, we provide genetic evidence that SIFa and SIFR promote sleep in Drosophila. Either genetic ablation of SIFa-expressing neurons in the pars intercerebralis (PI) or pan-neuronal depletion of SIFa expression shortened baseline sleep and reduced sleep-bout length, suggesting that it caused sleep fragmentation. Consistently, RNA interference-mediated knockdown of SIFR expression caused short sleep phenotypes as observed in SIFa-ablated or depleted flies. Using a panel of neuron-specific Gal4 drivers, we further mapped SIFR effects to subsets of PI neurons. Taken together, these results reveal a novel physiological role of the neuropeptide SIFa/SIFR pathway to regulate sleep through sleep-promoting neural circuits in the PI of adult fly brains.
URI
https://scholarworks.unist.ac.kr/handle/201301/4968
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84901404010
DOI
10.14348/molcells.2014.2371
ISSN
1016-8478
Appears in Collections:
SLS_Journal Papers
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