File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher

서판길

Suh, Pann-Ghill
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Loss of DJ-1 promotes browning of white adipose tissue in diet-induced obese mice

Author(s)
Silvester, Allwin JennifaAseer, Kanikkai RajaJang, Hyun-JunRyu, RiKwon, Eun-YoungPark, Jae GyuCho, Kiu-HyungChaudhari, Harmesh N.Choi, Myung-SookSuh, Pann-GhillYun, Jong Won
Issued Date
2018-11
DOI
10.1016/j.jnutbio.2018.07.004
URI
https://scholarworks.unist.ac.kr/handle/201301/49540
Fulltext
https://www.sciencedirect.com/science/article/pii/S0955286318303668?via%3Dihub
Citation
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v.61, pp.56 - 67
Abstract
The seminal discovery of browning of white adipose tissue (WAT) holds great promise for the treatment of obesity and metabolic syndrome. DJ-1 is evolutionarily conserved across species, and mutations in DJ-1 have been identified in Parkinson's disease. Higher levels of DJ-1 are associated with obesity, but the underlying mechanism is less understood. Here, we report the previously unappreciated role of DJ-1 in white adipocyte biology in mature models of obesity. We used DJ-1 knockout (KO) mouse models and wild-type littermates maintained on a normal diet or high-fat diet as well as in vitro cell models to show the direct effects of DJ-1 depletion on adipocyte phenotype, thermogenic capacity, fat metabolism, and microenvironment profile. Global DJ-1 KO mice show increased sympathetic input to WAT and beta 3-adrenergic receptor intracellular signaling, leading to a previously unrecognized compensatory mechanism through browning of WAT with associated characteristics, including high mitochondrial contents, reduced lipid accumulation, adequate vascularization and attenuated autophagy. DJ-1 KO mice had normal body weight, energy balance, and adiposity, which were associated with protective effects on healthy WAT expansion by hyperplasia. Our findings revealed that browning of inguinal WAT occurred in DJ-1 KO mice that do not show increased predisposition to obesity and suggest that such potential mechanism may overcome the adverse metabolic consequences of obesity independent of an effect on body weight. Here, we provide the first direct evidence that targeting DJ-1 in adipocyte metabolic health may offer a unique therapeutic strategy for the treatment of obesity.
Publisher
ELSEVIER SCIENCE INC
ISSN
0955-2863
Keyword (Author)
AutophagyBrowningDJ-1MitochondriaObesityWhite adipose tissue
Keyword
INFLAMMATIONHOMEOSTASISADIPOCYTESMETABOLISMGLUCOSEMOUSECELLS

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.