BROWSE

Related Researcher

Author's Photo

Kwon, Tae-Hyuk
Energy Recognition
Research Interests
  • Energy transfer, organic solar cells, supercapacitor, ultrasonic spray chemistry, dithienothiophene, iridium complexes, phosphorescent bioapplications

ITEM VIEW & DOWNLOAD

Analysing the mechanism of mitochondrial oxidation-induced cell death using a multifunctional iridium(III) photosensitiser

Cited 0 times inthomson ciCited 0 times inthomson ci
Title
Analysing the mechanism of mitochondrial oxidation-induced cell death using a multifunctional iridium(III) photosensitiser
Author
Lee, ChaiheonNam, Jung SeungLee, Chae GyuPark, MingyuYoo, Chang-MORhee, Hyun-WooSeo, Jeong KonKwon, Tae-Hyuk
Issue Date
2021-01
Publisher
Nature Publishing Group
Citation
NATURE COMMUNICATIONS, v.12, pp.2021
Abstract
Mitochondrial oxidation-induced cell death, a physiological process triggered by various cancer therapeutics to induce oxidative stress on tumours, has been challenging to investigate owing to the difficulties in generating mitochondria-specific oxidative stress and monitoring mitochondrial responses simultaneously. Accordingly, to the best of our knowledge, the relationship between mitochondrial protein oxidation via oxidative stress and the subsequent cell death-related biological phenomena has not been defined. Here, we developed a multifunctional iridium(III) photosensitiser, Ir-OA, capable of inducing substantial mitochondrial oxidative stress and monitoring the corresponding change in viscosity, polarity, and morphology. Photoactivation of Ir-OA triggers chemical modifications in mitochondrial protein-crosslinking and oxidation (i.e., oxidative phosphorylation complexes and channel and translocase proteins), leading to microenvironment changes, such as increased microviscosity and depolarisation. These changes are strongly related to cell death by inducing mitochondrial swelling with excessive fission and fusion. We suggest a potential mechanism from mitochondrial oxidative stress to cell death based on proteomic analyses and phenomenological observations.
URI
https://scholarworks.unist.ac.kr/handle/201301/49477
URL
https://www.nature.com/articles/s41467-020-20210-3
DOI
10.1038/s41467-020-20210-3
ISSN
2041-1723
Appears in Collections:
CHM_Journal Papers
UCRF_Journal Papers
Files in This Item:
Nat Commun 2021_ Ir-OA.pdf Download

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU