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Jeong, Hoon Eui
Multiscale Biomimetics & Manufacturing Lab
Research Interests
  • Biomimetics
  • Multiscale manufacturing
  • Micro/nanofabrication

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A Tough Polysaccharide-Based Hydrogel with an On-Demand Dissolution Feature for Chronic Wound Care through Light-Induced Ultrafast Degradation

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Title
A Tough Polysaccharide-Based Hydrogel with an On-Demand Dissolution Feature for Chronic Wound Care through Light-Induced Ultrafast Degradation
Author
Cui, NingHan, KaiZhou, ChuqingSeong, MinhoLu, TingliJeong, Hoon Eui
Issue Date
2020-12
Publisher
American Chemical Society
Citation
ACS APPLIED BIO MATERIALS, v.3, no.12, pp.8338 - 8343
Abstract
Repeatedly changing dressings during wound healing can cause unbearable physical pain for patients with chronic skin injury. In this study, we designed a tough hydrogel-based dressing that can be degraded in an on-demand fashion for advanced chronic wound care. The resultant hydrogel dressing could be rapidly dissolved within 100 s after wetting with lithium phenyl(2,4,6-trimethylbenzonyl)phosphinate solution under low-power (1 W) ultraviolet (UV) irradiation (365 nm) owing to the breakage of disulfide bonds. This UV-triggered on-demand dissolution of tough hydrogels allows for a facile dressing replacement without causing tissue damage or pain, which is of great potential for clinical utilization.
URI
https://scholarworks.unist.ac.kr/handle/201301/49290
URL
https://pubs.acs.org/doi/10.1021/acsabm.0c00554
DOI
10.1021/acsabm.0c00554
ISSN
2576-6422
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