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Kwon, Hyug Moo
Immunometabolism and Cancer Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorder, Genomic instability

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THE CANINE BETAINE GAMMA-AMINO-N-BUTYRIC ACID TRANSPORTER GENE - DIVERSE MESSENGER-RNA ISOFORMS ARE REGULATED BY HYPERTONICITY AND ARE EXPRESSED IN A TISSUE-SPECIFIC MANNER

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dc.contributor.author TAKENAKA, M ko
dc.contributor.author BAGNASCO, SM ko
dc.contributor.author PRESTON, AS ko
dc.contributor.author UCHIDA, S ko
dc.contributor.author YAMAUCHI, A ko
dc.contributor.author Kwon, H. Moo ko
dc.contributor.author HANDLER, JS ko
dc.date.available 2014-06-09T02:38:09Z -
dc.date.created 2014-06-03 ko
dc.date.issued 1995-02 ko
dc.identifier.citation PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.92, no.4, pp.1072 - 1076 ko
dc.identifier.issn 0027-8424 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/4914 -
dc.description.abstract The Na+- and Cl--coupled betaine transporter, designated BGT1, a member of the neurotransmitter transporter gene family, is responsible for accumulation of betaine in hypertonic Madin-Darby canine kidney (MDCK) cells and presumably in the hypertonic renal medulla, The canine gene for the betaine gamma-amino-n-butyric acid transporter has been cloned and analyzed, The gene extends over 28 kb and consists of 18 exons, The 5' end of the gene has three alternative first exons (1A, 1B, and 1C+D), Analysis of BGT1 mRNA revealed that there is considerable divergence in the 5' untranslated sequence resulting from three different 5' end motifs (A, B, and C) followed by an alternative motif (D) as well as two internal acceptor sites for splicing, Eight kinds of BGT1 mRNA were classified into three types (A, B, and C) according to the 5' end sequence, Northern blot analysis using probes specific for the A, B, or C motif revealed that hypertonicity induces all three types in MDCK cells, Reverse transcription and polymerase chain reaction showed that each type was expressed in a tissue-specific manner. Primer extension and/or RNase protection assays as well as transfection assays into MDCK cells demonstrated that exons 1A, 1B, and 1C+D have independent transcription initiation sites under control of independent promoters, Diverse mRNA isoforms are regulated by hypertonicity and are expressed in a tissue-specific manner. ko
dc.description.statementofresponsibility open -
dc.language 영어 ko
dc.publisher NATL ACAD SCIENCES ko
dc.title THE CANINE BETAINE GAMMA-AMINO-N-BUTYRIC ACID TRANSPORTER GENE - DIVERSE MESSENGER-RNA ISOFORMS ARE REGULATED BY HYPERTONICITY AND ARE EXPRESSED IN A TISSUE-SPECIFIC MANNER ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-0028985147 ko
dc.identifier.wosid A1995QG77000029 ko
dc.type.rims ART ko
dc.description.wostc 58 *
dc.date.tcdate 2015-05-06 *
dc.identifier.doi 10.1073/pnas.92.4.1072 ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0028985147 ko
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