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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 979 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 975 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 213 | - |
dc.contributor.author | Kwon, H. Moo | - |
dc.contributor.author | ITOH, T | - |
dc.contributor.author | RIM, JS | - |
dc.contributor.author | HANDLER, JS | - |
dc.date.accessioned | 2023-12-22T12:41:33Z | - |
dc.date.available | 2023-12-22T12:41:33Z | - |
dc.date.created | 2014-06-03 | - |
dc.date.issued | 1995-08 | - |
dc.description.abstract | Kidney derived MDCK cells are protected from the stress of hypertonicity by accumulating compatible osmolytes. Accumulation of the compatible osmolytes myo-inositol and betaine is driven by hypertonicity-induced stimulation of transcription of the genes coding for the myoinositol cotransporter and the betaine cotransporter. We tested the importance of the mitogen-activated protein kinase pathway in transcriptional activation of the genes for the two osmolytes cotransporters because this kinase pathway is rapidly activated when cells are exposed to hypertonicity and a mitogen-activated protein kinase pathway is essential for the osmo-protective transcriptional response of yeast to hypertonicity. Eliminating the activation of mitogen-activated protein kinase did not block the hypertonicity induced increase in accumulation of osmolyte transporter mRNA. | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.213, no.3, pp.975 - 979 | - |
dc.identifier.doi | 10.1006/bbrc.1995.2224 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.scopusid | 2-s2.0-0028978661 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/4913 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0028978661 | - |
dc.identifier.wosid | A1995RQ72700033 | - |
dc.language | 영어 | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | THE MAP KINASE CASCADE IS NOT ESSENTIAL FOR TRANSCRIPTIONAL STIMULATION OF OSMOLYTE TRANSPORTER GENES | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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