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Kwon, Hyug Moo
Immunometabolism and Cancer Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorder, Genomic instability

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Transcription of the sodium/myo-inositol cotransporter gene is regulated by multiple tonicity-responsive enhancers spread over 50 kilobase pairs in the 5 '-flanking region

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dc.contributor.author Rim, JS ko
dc.contributor.author Atta, MG ko
dc.contributor.author Dahl, SC ko
dc.contributor.author Berry, GT ko
dc.contributor.author Handler, JS ko
dc.contributor.author Kwon, H. Moo ko
dc.date.available 2014-06-09T02:38:04Z -
dc.date.created 2014-06-05 ko
dc.date.issued 1998-08 ko
dc.identifier.citation JOURNAL OF BIOLOGICAL CHEMISTRY, v.273, no.32, pp.20615 - 20621 ko
dc.identifier.issn 0021-9258 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/4908 -
dc.description.abstract he sodium/myo-inositol cotransporter is a plasma membrane protein responsible for concentrative cellular accumulation of myo-inositol in a variety of tissues. When cells in kidney and brain are exposed to a hyperosmolar salt condition (hypertonicity) due to the operation of urinary concentration mechanism and pathological conditions, respectively; they survive the stress of hypertonicity by raising the cellular concentration of myo-inositol. Transcription of the sodium/myo-inositol cotransporter gene is markedly stimulated in response to hypertonicity, leading to an increase in the activity of the cotransporter, which in turn drives the osmoprotective accumulation of myo-inositol. To understand the molecular mechanisms by which hypertonicity stimulates transcription, we analyzed the BI-flanking region of the cotransporter gene for cis-acting regulatory sequences. We identified five tonicity-responsive enhancers that are scattered over 50 kilobase pairs. All the enhancers are variations of the same type of enhancer interacting with the transcription factor named tonicity-responsive enhancer binding protein. In vivo methylation experiments demonstrated that exposure of cells to hypertonicity increases the binding of tonicity-responsive enhancer binding protein to the enhancer sites, indicating that all of these enhancers are involved in the transcriptional stimulation. We conclude that the sodium/myo-inositol cotransporter gene is regulated by a large region (similar to 50 kilobase pairs) upstream of the gene. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC ko
dc.title Transcription of the sodium/myo-inositol cotransporter gene is regulated by multiple tonicity-responsive enhancers spread over 50 kilobase pairs in the 5 '-flanking region ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-0032493754 ko
dc.identifier.wosid 000075305400096 ko
dc.type.rims ART ko
dc.description.wostc 113 *
dc.description.scopustc 111 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-06-05 *
dc.identifier.doi 10.1074/jbc.273.32.20615 ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032493754 ko
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