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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C


RGS2 promotes formation of neurites by stimulating microtubule polymerization

DC Field Value Language Heo, Kyun ko Ha, Sang Hoon ko Chae, Young Chan ko Lee, Sukmook ko Oh, Yong-Seok ko Kim, Yun-Hee ko Kim, Sun-Hee ko Kim, Jung Hwan ko Mizoguchi, Akira ko Itoh, Tomohiko J. ko Kwon, H. Moo ko Ryu, Sung Ho ko Suh, Pann-Ghill ko 2014-06-09T02:37:48Z - 2014-06-03 ko 2006-12 ko
dc.identifier.citation CELLULAR SIGNALLING, v.18, no.12, pp.2182 - 2192 ko
dc.identifier.issn 0898-6568 ko
dc.identifier.uri -
dc.description.abstract Regulator of G-protein signaling (RGS) proteins interact with α subunits of heterotrimeric G-proteins via the RGS domain and attenuate their activity by accelerating GTPase activity. RGS2, a member of the RGS family, regulates synaptic development via hereto unknown mechanism. In this study, we found that RGS2 directly interacted with tubulin via a short region at the N-terminus: amino acids 41-60. RGS2 enhanced microtubule polymerization in vitro, and the tubulin binding region was necessary and sufficient for this activity. In Vero cells, polymerization of microtubule was stimulated when peptides containing the tubulin binding region were microinjected. Immunocytochemical analysis showed that endogenous RGS2 was localized at the termini of neurites in differentiated PC12 cells. Over-expression of RGS2 enhanced the nerve growth factor-induced neurite outgrowth in PC12 cells, while specific knock-down of endogenous RGS2 suppressed the neurite outgrowth. These findings demonstrate that RGS2 contributes to the neuronal cell differentiation via regulation of microtubule dynamics. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher ELSEVIER SCIENCE INC ko
dc.title RGS2 promotes formation of neurites by stimulating microtubule polymerization ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-33750312906 ko
dc.identifier.wosid 000242266400012 ko
dc.type.rims ART ko
dc.description.wostc 29 *
dc.description.scopustc 23 * 2015-05-06 * 2014-06-03 *
dc.identifier.doi 10.1016/j.cellsig.2006.05.006 ko
dc.identifier.url ko
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