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Kwon, Hyug Moo
Immunometabolism and Cancer Lab.
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dc.citation.endPage f77 -
dc.citation.number 1 -
dc.citation.startPage f67 -
dc.citation.title AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY -
dc.citation.volume 296 -
dc.contributor.author Kim, Yu-Mi -
dc.contributor.author Kim, Wan-Young -
dc.contributor.author Lee, Hyun-Wook -
dc.contributor.author Kim, Jin -
dc.contributor.author Kwon, H. Moo -
dc.contributor.author Klein, Janet D. -
dc.contributor.author Sands, Jeff M -
dc.contributor.author Kim, Dongun -
dc.date.accessioned 2023-12-22T08:11:45Z -
dc.date.available 2023-12-22T08:11:45Z -
dc.date.created 2014-06-05 -
dc.date.issued 2009-01 -
dc.description.abstract Kim YM, Kim WY, Lee HW, Kim J, Kwon HM, Klein JD, Sands JM, Kim D. Urea and NaCl regulate UT-A1 urea transporter in opposing directions via TonEBP pathway during osmotic diuresis. Am J Physiol Renal Physiol 296: F67-F77, 2009. First published October 22, 2008; doi: 10.1152/ajprenal.00143.2008.-In our previous studies of varying osmotic diuresis, UT-A1 urea transporter increased when urine and inner medullary (IM) interstitial urea concentration decreased. The purposes of this study were to examine 1) whether IM interstitial tonicity changes with different urine urea concentrations during osmotic dieresis and 2) whether the same result occurs even if the total urinary solute is decreased. Rats were fed a 4% high-salt diet (HSD) or a 5% high-urea diet (HUD) for 2 wk and compared with the control rats fed a regular diet containing 1% NaCl. The urine urea concentration decreased in HSD but increased in HUD. In the IM, UT-A1 and UT-A3 urea transporters, CLC-K1 chloride channel, and tonicity-enhanced binding protein (TonEBP) transcription factor were all increased in HSD and decreased in HUD. Next, rats were fed an 8% low-protein diet (LPD) or a 0.4% low-salt diet (LSD) to decrease the total urinary solute. Urine urea concentration significantly decreased in LPD but significantly increased in LSD. Rats fed the LPD had increased UT-A1 and UT-A3 in the IM base but decreased in the IM tip, resulting in impaired urine concentrating ability. The LSD rats had decreased UT-A1 and UT-A3 in both portions of the IM. CLC-K1 and TonEBP were unchanged by LPD or LSD. We conclude that changes in CLC-K1, UT-A1, UT-A3, and TonEBP play important roles in the renal response to osmotic diuresis in an attempt to minimize changes in plasma osmolality and maintain water homeostasis. -
dc.identifier.bibliographicCitation AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v.296, no.1, pp.f67 - f77 -
dc.identifier.doi 10.1152/ajprenal.00143.2008 -
dc.identifier.issn 1931-857X -
dc.identifier.scopusid 2-s2.0-58849150350 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/4885 -
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=58849150350 -
dc.identifier.wosid 000262101200008 -
dc.language 영어 -
dc.publisher AMER PHYSIOLOGICAL SOC -
dc.title Urea and NaCl regulate UT-A1 urea transporter in opposing directions via TonEBP pathway during osmotic diuresis -
dc.type Article -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor UT-A3 urea transporter -
dc.subject.keywordAuthor CLC-K1 chloride channel -
dc.subject.keywordAuthor TonEBP transcription factor -
dc.subject.keywordPlus ENHANCER-BINDING PROTEIN -
dc.subject.keywordPlus CLC CHLORIDE CHANNELS -
dc.subject.keywordPlus THIN DESCENDING-LIMB -
dc.subject.keywordPlus DIABETES-MELLITUS -
dc.subject.keywordPlus BRATTLEBORO RATS -
dc.subject.keywordPlus MESSENGER-RNA -
dc.subject.keywordPlus INITIAL IMCD -
dc.subject.keywordPlus EXPRESSION -
dc.subject.keywordPlus TONICITY -
dc.subject.keywordPlus VASOPRESSIN -

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