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Kwon, Hyug Moo
Immunometabolism and Cancer Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorder, Genomic instability

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Polyol pathway and diabetic nephropathy revisited: Early tubular cell changes and glomerulopathy in diabetic mice overexpressing human aldose reductase

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dc.contributor.author (Hashimoto, Yasuhiro ko
dc.contributor.author Yamagishi, Shin-Ichiro ko
dc.contributor.author Mizukami, Hiroki ko
dc.contributor.author Yabe-Nishimura, Chihiro ko
dc.contributor.author Lim, Sun Woo ko
dc.contributor.author Kwon, H. Moo ko
dc.contributor.author Yagihashi, Soroku ko
dc.date.available 2014-06-09T02:37:38Z -
dc.date.created 2014-06-03 ko
dc.date.issued 2011-04 ko
dc.identifier.citation JOURNAL OF DIABETES INVESTIGATION, v.2, no.2, pp.111 - 122 ko
dc.identifier.issn 2040-1116 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/4882 -
dc.description.abstract Aims/Introduction: The polyol pathway has long been involved in the pathogenesis of diabetic nephropathy. It remains still unclear, however, how the polyol pathway is implicated in this process. We explored the effects of the enhanced polyol pathway on renocortical tubular cells and glomeruli in experimentally-induced diabetes. Materials and Methods: Transgenic mice (Tg) overexpressing human aldose reductase were made diabetic by streptozotocin and followed for 8 weeks. Renocortical pathology, expressions of tonicity-responsive enhancer binding protein (TonEBP) and carboxymethyllysine of advanced glycation end-products, were examined. Wild-type non-transgenic mice (Wt) were also made diabetic and served as controls. Results: Diabetic Tg showed augmented expression of TonEBP in renocortical tubular cells with vacuolated degenerative changes. These structural changes were associated with pronounced deposition of carboxymethyllysine. There was a significant increase in kidney weight, glomerular size, and mesangial area in diabetic animals and there was a trend for more severe changes in these measures in diabetic transgenic mice compared with those in control diabetic mice. Treatment with aldose reductase inhibitor significantly prevented polyol accumulation, mesangial expansion and expressions of TonEBP and carboxymethyllysine in diabetic Tg, but its effects on the renal structure were equivocal in control diabetic Wt. Conclusions: Our findings suggest that tubuloglomerular change might contribute to early diabetic nephropathy under the influence of the enhanced polyol pathway. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher WILEY-BLACKWELL ko
dc.title Polyol pathway and diabetic nephropathy revisited: Early tubular cell changes and glomerulopathy in diabetic mice overexpressing human aldose reductase ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-79961034723 ko
dc.identifier.wosid 000289909000006 ko
dc.type.rims ART ko
dc.description.wostc 1 *
dc.description.scopustc 1 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-06-03 *
dc.identifier.doi 10.1111/j.2040-1124.2010.00071.x ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79961034723 ko
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