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Kwon, Hyug Moo
Immunometabolism and Cancer Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorder, Genomic instability

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MOLECULAR-CLONING OF THE CDNA FOR AN MDCK CELL NA+-DEPENDENT AND CL--DEPENDENT TAURINE TRANSPORTER THAT IS REGULATED BY HYPERTONICITY

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dc.contributor.author UCHIDA, S ko
dc.contributor.author Kwon, H. Moo ko
dc.contributor.author YAMAUCHI, A ko
dc.contributor.author PRESTON, AS ko
dc.contributor.author MARUMO, F ko
dc.contributor.author HANDLER, JS ko
dc.date.available 2014-06-03T00:54:47Z -
dc.date.created 2014-06-02 ko
dc.date.issued 1992-09 ko
dc.identifier.citation PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.89, no.17, pp.8230 - 8234 ko
dc.identifier.issn 0027-8424 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/4864 -
dc.description.abstract Cells in the hypertonic renal medulla maintain their intracellular ion concentration at isotonic levels, despite much higher concentrations of extracellular electrolytes, by accumulating high concentrations of nonperturbing small organic solutes termed osmolytes. Taurine has been identified as a nonperturbing osmolyte in the renal medulla and Madin-Darby canine kidney (MDCK) cells. In hypertonic medium, the increased accumulation of taurine in MDCK cells is the result of increased activity of a Na+- and Cl--dependent taurine transporter. We have isolated a cDNA encoding a Na+- and Cl--dependent taurine transporter, whose sequence corresponds to a protein of 655 amino acids with significant amino acid sequence similarity to previously cloned Na+- and Cl--dependent transporters, including the MDCK cell betaine/gamma-aminobutyric acid transporter and several brain neurotransmitter transporters. Northern hybridization indicates that mRNA for the taurine transporter is present in renal cortex and medulla, ileal mucosa, brain, liver, and heart. The abundance of mRNA for the taurine transporter is increased in MDCK cells cultured in hypertonic medium, suggesting that regulation of transport activity by medium hypertonicity occurs at the level of mRNA accumulation ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher NATL ACAD SCIENCES ko
dc.title MOLECULAR-CLONING OF THE CDNA FOR AN MDCK CELL NA+-DEPENDENT AND CL--DEPENDENT TAURINE TRANSPORTER THAT IS REGULATED BY HYPERTONICITY ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-0026774290 ko
dc.identifier.wosid A1992JL61400080 ko
dc.type.rims ART ko
dc.description.wostc 293 *
dc.date.tcdate 2015-05-06 *
dc.identifier.doi 10.1073/pnas.89.17.8230 ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0026774290 ko
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