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Kwon, Hyug Moo
Immunometabolism and Cancer Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorder, Genomic instability


Multiple domains of TonEBP cooperate to stimulate transcription in response to hypertonicity

DC Field Value Language Do Lee, S ko Colla, E ko Sheen, MR ko Na, KY ko Kwon, H. Moo ko 2014-06-03T00:54:36Z - 2014-06-02 ko 2003-11 ko
dc.identifier.citation JOURNAL OF BIOLOGICAL CHEMISTRY, v.278, no.48, pp.47571 - 47577 ko
dc.identifier.issn 0021-9258 ko
dc.identifier.uri -
dc.description.abstract Tonicity-responsive enhancer binding protein (TonEBP), also known as NFAT5, belongs to the Rel family of transcriptional activators. In the kidney medulla and thymus, TonEBP plays a major role in protecting renal cells and T cells from the deleterious effects of ambient hypertonicity. TonEBP is stimulated by hypertonicity via several pathways: increased expression of protein, nuclear translocation, and increased transactivation. In this study, we identified five domains of TonEBP involved in transactivation. The two conserved glutamine repeats were not involved in transactivation. There were three activation domains that could stimulate transcription independently. In addition, there were two modulation domains that potentiated the activity of the activation domains. One of the activation domains is unique to a splice isoform that is more active than others, indicating that alternative splicing can affect the activity of TonEBP. Another activation domain and one of the modulation domains were stimulated by hypertonicity. All the five domains acted in synergy in every combination. Although overall phosphorylation of TonEBP increased in response to hypertonicity, phosphorylation of the activation and modulation domains did not increase in isolation. In sum, TonEBP possesses far more elaborate domains involved in transactivation compared with other Rel proteins. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.title Multiple domains of TonEBP cooperate to stimulate transcription in response to hypertonicity ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-0348111474 ko
dc.identifier.wosid 000186731400029 ko
dc.type.rims ART ko
dc.description.wostc 1 *
dc.description.scopustc 36 * 2015-05-06 * 2014-06-02 *
dc.identifier.doi 10.1074/jbc.M308795200 ko
dc.identifier.url ko
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