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DC Field | Value | Language |
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dc.citation.endPage | 1397 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1389 | - |
dc.citation.title | NATURE CELL BIOLOGY | - |
dc.citation.volume | 8 | - |
dc.contributor.author | Choi, Jang Hyun | - |
dc.contributor.author | Kim, Hyeon Soo | - |
dc.contributor.author | Kim, Sun-Hee | - |
dc.contributor.author | Yang, Yong Ryoul | - |
dc.contributor.author | Bae, Yun Soo | - |
dc.contributor.author | Chang, Jong-Soo | - |
dc.contributor.author | Kwon, H. Moo | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.date.accessioned | 2023-12-22T09:40:00Z | - |
dc.date.available | 2023-12-22T09:40:00Z | - |
dc.date.created | 2014-06-03 | - |
dc.date.issued | 2006-12 | - |
dc.description.abstract | Growth hormone binds to its membrane receptor (GHR), whereby it regulates many cellular functions, including proliferation, differentiation and chemotaxis. However, although the activation of growth hormone-mediated signalling is well understood, the precise mechanism responsible for its regulation has not been elucidated. Here, we demonstrate that phospholipase C gamma 1 (PLC gamma 1) modulates the action of growth hormone-mediated signalling by interacting with tyrosine kinase Jak2 (janus kinase 2) in a growth hormone-dependent manner. In the absence of PLC gamma 1 (PLC gamma 1(-/-)), growth hormone-induced JAK2 and STAT5 phosphorylation significantly increased in mouse embryonic fibroblasts (MEFs). Furthermore, the re-expression of PLC gamma 1 reduced growth hormone-induced Jak2 activation. Growth hormone-induced Jak2 phosphorylation was enhanced by siRNA-specific knockdown of PLC gamma 1. Interestingly, PLC gamma 1 physically linked Jak2 and protein tyrosine phosphatase-1B (PTP-1B) by binding to both using different domains, and this process was implicated in the modulation of cytokine signalling through Jak2. In addition, in PLC gamma 1(-/-) MEFs, growth hormone-dependent c-Fos activation was upregulated and growth hormone-induced proliferation was potentiated. These results suggest that PLC gamma 1 has a key function in the regulation of growth hormone-mediated signalling by negatively regulating Jak2 activation. | - |
dc.identifier.bibliographicCitation | NATURE CELL BIOLOGY, v.8, no.12, pp.1389 - 1397 | - |
dc.identifier.doi | 10.1038/ncb1509 | - |
dc.identifier.issn | 1465-7392 | - |
dc.identifier.scopusid | 2-s2.0-33751536492 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/4850 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33751536492 | - |
dc.identifier.wosid | 000242419800015 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Phospholipase C gamma 1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | NUCLEOTIDE EXCHANGE FACTOR | - |
dc.subject.keywordPlus | FACTOR-RECEPTOR | - |
dc.subject.keywordPlus | INSULIN SENSITIVITY | - |
dc.subject.keywordPlus | C-FOS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | 1B | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | ENDOCYTOSIS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | FAILURE | - |
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