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Kwon, Hyug Moo
Immunometabolism and Cancer Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorder, Genomic instability

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Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes

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dc.contributor.author Navarro, Paola ko
dc.contributor.author Chiong, Mario ko
dc.contributor.author Volkwein, Karen ko
dc.contributor.author Moraga, Francisco ko
dc.contributor.author Ocaranza, Maria Paz ko
dc.contributor.author Jalil, Jorge E. ko
dc.contributor.author Lim, Sun Woo ko
dc.contributor.author Kim, Jeong-Ah ko
dc.contributor.author Kwon, H. Moo ko
dc.contributor.author Lavandero, Sergio ko
dc.date.available 2014-06-03T00:54:32Z -
dc.date.created 2014-06-03 ko
dc.date.issued 2008-07 ko
dc.identifier.citation BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.372, no.2, pp.326 - 330 ko
dc.identifier.issn 0006-291X ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/4849 -
dc.description.abstract Changes in cardiac osmolarity occur in myocardial infarction. Osmoregulatory mechanism may, therefore, play a Crucial role in cardiomyocyte survival. Tonicity-responsive enhancer binding protein (TonEBP) is a key transcription factor participating in the adaptation of cells to increases in tonicity. However, it is unknown whether cardiac TonEBP is activated by tonicity. Hypertonicity activated transcriptional activity of TonEBP, increased the amounts of both TonEBP mRNA and protein, and induced both the mRNA and protein of TonEBP target genes (aldose reductase and heat shock protein-70). Hypotonicity decreased the amount of TonEBP protein indicating bidirectional osmoregulation of this transcription factor. Adenoviral expression of a dominant negative TonEBP suppressed the hypertonicity-dependent increase of aldose reductase protein. These results indicated that TonEBP controls osmoregulatory mechanisms in cardiomyocytes. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher ACADEMIC PRESS INC ELSEVIER SCIENCE ko
dc.title Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-44649198309 ko
dc.identifier.wosid 000256941000010 ko
dc.type.rims ART ko
dc.description.wostc 7 *
dc.description.scopustc 8 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-06-03 *
dc.identifier.doi 10.1016/j.bbrc.2008.05.067 ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=44649198309 ko
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