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Kwon, Hyug Moo
Immunometabolism and Cancer Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorder, Genomic instability


Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes

DC Field Value Language Navarro, Paola ko Chiong, Mario ko Volkwein, Karen ko Moraga, Francisco ko Ocaranza, Maria Paz ko Jalil, Jorge E. ko Lim, Sun Woo ko Kim, Jeong-Ah ko Kwon, H. Moo ko Lavandero, Sergio ko 2014-06-03T00:54:32Z - 2014-06-03 ko 2008-07 ko
dc.identifier.citation BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.372, no.2, pp.326 - 330 ko
dc.identifier.issn 0006-291X ko
dc.identifier.uri -
dc.description.abstract Changes in cardiac osmolarity occur in myocardial infarction. Osmoregulatory mechanism may, therefore, play a Crucial role in cardiomyocyte survival. Tonicity-responsive enhancer binding protein (TonEBP) is a key transcription factor participating in the adaptation of cells to increases in tonicity. However, it is unknown whether cardiac TonEBP is activated by tonicity. Hypertonicity activated transcriptional activity of TonEBP, increased the amounts of both TonEBP mRNA and protein, and induced both the mRNA and protein of TonEBP target genes (aldose reductase and heat shock protein-70). Hypotonicity decreased the amount of TonEBP protein indicating bidirectional osmoregulation of this transcription factor. Adenoviral expression of a dominant negative TonEBP suppressed the hypertonicity-dependent increase of aldose reductase protein. These results indicated that TonEBP controls osmoregulatory mechanisms in cardiomyocytes. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.title Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-44649198309 ko
dc.identifier.wosid 000256941000010 ko
dc.type.rims ART ko
dc.description.wostc 7 *
dc.description.scopustc 8 * 2015-05-06 * 2014-06-03 *
dc.identifier.doi 10.1016/j.bbrc.2008.05.067 ko
dc.identifier.url ko
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