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권혁무

Kwon, Hyug Moo
Immunometabolism and Cancer Lab.
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dc.citation.endPage 3474 -
dc.citation.number 19 -
dc.citation.startPage 3459 -
dc.citation.title MOLECULAR BIOLOGY OF THE CELL -
dc.citation.volume 21 -
dc.contributor.author Roth, Isabelle -
dc.contributor.author Leroy, Valerie -
dc.contributor.author Kwon, H. Moo -
dc.contributor.author Martin, Pierre-Yves -
dc.contributor.author Feraille, Eric -
dc.contributor.author Hasler, Udo -
dc.date.accessioned 2023-12-22T06:42:47Z -
dc.date.available 2023-12-22T06:42:47Z -
dc.date.created 2014-06-02 -
dc.date.issued 2010-10 -
dc.description.abstract Tonicity-responsive binding-protein (TonEBP or NFAT5) is a widely expressed transcription factor whose activity is regulated by extracellular tonicity. TonEBP plays a key role in osmoprotection by binding to osmotic response element/TonE elements of genes that counteract the deleterious effects of cell shrinkage. Here, we show that in addition to this "classical" stimulation, TonEBP protects cells against hypertonicity by enhancing nuclear factor-kappa B (NF-kappa B) activity. We show that hypertonicity enhances NF-kappa B stimulation by lipopolysaccharide but not tumor necrosis factor-alpha, and we demonstrate overlapping protein kinase B (Akt)-dependent signal transduction pathways elicited by hypertonicity and transforming growth factor-alpha. Activation of p38 kinase by hypertonicity and downstream activation of Akt play key roles in TonEBP activity, I kappa B alpha degradation, and p65 nuclear translocation. TonEBP affects neither of these latter events and is itself insensitive to NF-kappa B signaling. Rather, we reveal a tonicity-dependent interaction between TonEBP and p65 and show that NF-kappa B activity is considerably enhanced after binding of NF-kappa B-TonEBP complexes to kappa B elements of NF-kappa B-responsive genes. We demonstrate the key roles of TonEBP and Akt in renal collecting duct epithelial cells and in macrophages. These findings reveal a novel role for TonEBP and Akt in NF-kappa B activation on the onset of hypertonic challenge. -
dc.identifier.bibliographicCitation MOLECULAR BIOLOGY OF THE CELL, v.21, no.19, pp.3459 - 3474 -
dc.identifier.doi 10.1091/mbc.E10-02-0133 -
dc.identifier.issn 1059-1524 -
dc.identifier.scopusid 2-s2.0-77958055648 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/4846 -
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77958055648 -
dc.identifier.wosid 000282275600017 -
dc.language 영어 -
dc.publisher AMER SOC CELL BIOLOGY -
dc.title Osmoprotective Transcription Factor NFAT5/TonEBP Modulates Nuclear Factor-kappa B Activity -
dc.type Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -

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