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DC Field | Value | Language |
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dc.citation.endPage | 20671 | - |
dc.citation.number | 34 | - |
dc.citation.startPage | 20662 | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 117 | - |
dc.contributor.author | Weber, Jessica A. | - |
dc.contributor.author | Park, Seung Gu | - |
dc.contributor.author | Luria, Victor | - |
dc.contributor.author | Jeon, Sungwon | - |
dc.contributor.author | Kim, Hak-Min | - |
dc.contributor.author | Jeon, Yeonsu | - |
dc.contributor.author | Bhak, Youngjune | - |
dc.contributor.author | Jun, Je Hun | - |
dc.contributor.author | Kim, Sang Wha | - |
dc.contributor.author | Hong, Won Hee | - |
dc.contributor.author | Lee, Semin | - |
dc.contributor.author | Cho, Yun Sung | - |
dc.contributor.author | Karger, Amir | - |
dc.contributor.author | Cain, John W. | - |
dc.contributor.author | Manica, Andrea | - |
dc.contributor.author | Kim, Soonok | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Edwards, Jeremy S. | - |
dc.contributor.author | Bhak, Jong | - |
dc.contributor.author | Church, George M. | - |
dc.date.accessioned | 2023-12-21T17:08:55Z | - |
dc.date.available | 2023-12-21T17:08:55Z | - |
dc.date.created | 2020-10-12 | - |
dc.date.issued | 2020-08 | - |
dc.description.abstract | The endangered whale shark (Rhincodon typus) is the largest fish on Earth and a long-lived member of the ancient Elasmobranchii Glade. To characterize the relationship between genome features and biological traits, we sequenced and assembled the genome of the whale shark and compared its genomic and physiological features to those of 83 animals and yeast. We examined the scaling relationships between body size, temperature, metabolic rates, and genomic features and found both general correlations across the animal kingdom and features specific to the whale shark genome. Among animals, increased lifespan is positively correlated to body size and metabolic rate. Several genomic traits also significantly correlated with body size, including intron and gene length. Our large-scale comparative genomic analysis uncovered general features of metazoan genome architecture: Guanine and cytosine (GC) content and codon adaptation index are negatively correlated, and neural connectivity genes are longer than average genes in most genomes. Focusing on the whale shark genome, we identified multiple features that significantly correlate with life-span. Among these were very long gene length, due to introns being highly enriched in repetitive elements such as CR1-like long interspersed nuclear elements, and considerably longer neural genes of several types, including connectivity, activity, and neuro-degeneration genes. The whale shark genome also has the second slowest evolutionary rate observed in vertebrates to date. Our comparative genomics approach uncovered multiple genetic features associated with body size, metabolic rate, and lifespan and showed that the whale shark is a promising model for studies of neural architecture and lifespan. | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.117, no.34, pp.20662 - 20671 | - |
dc.identifier.doi | 10.1073/pnas.1922576117 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.scopusid | 2-s2.0-85090069522 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/48336 | - |
dc.identifier.url | https://www.pnas.org/content/117/34/20662 | - |
dc.identifier.wosid | 000572978200016 | - |
dc.language | 영어 | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | The whale shark genome reveals how genomic and physiological properties scale with body size | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | metabolic rate | - |
dc.subject.keywordAuthor | neural genes | - |
dc.subject.keywordAuthor | whale shark | - |
dc.subject.keywordAuthor | lifespan | - |
dc.subject.keywordAuthor | body size | - |
dc.subject.keywordPlus | METABOLIC-RATE | - |
dc.subject.keywordPlus | DNA EVOLUTION | - |
dc.subject.keywordPlus | LIFE-HISTORY | - |
dc.subject.keywordPlus | CODON USAGE | - |
dc.subject.keywordPlus | GC-CONTENT | - |
dc.subject.keywordPlus | TEMPERATURE | - |
dc.subject.keywordPlus | DYNAMICS | - |
dc.subject.keywordPlus | ALIGNMENT | - |
dc.subject.keywordPlus | INSIGHTS | - |
dc.subject.keywordPlus | BIOLOGY | - |
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