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Kwon, Hyug Moo
Immunometabolism and Cancer Lab.
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dc.citation.endPage F23 -
dc.citation.number 1 -
dc.citation.startPage F20 -
dc.citation.title AMERICAN JOURNAL OF PHYSIOLOGY -
dc.citation.volume 264 -
dc.contributor.author YAMAUCHI, A -
dc.contributor.author UCHIDA, S -
dc.contributor.author PRESTON, AS -
dc.contributor.author Kwon, H. Moo -
dc.contributor.author HANDLER, JS -
dc.date.accessioned 2023-12-22T13:06:52Z -
dc.date.available 2023-12-22T13:06:52Z -
dc.date.created 2014-05-30 -
dc.date.issued 1993-01 -
dc.description.abstract Myo-inositol is a major compatible osmolyte accumulated in the hypertonic renal medulla and in Madin-Darby canine kidney (MDCK) cells cultured in hypertonic media. Myo-inositol is taken up by MDCK cells on a Na+-coupled transporter whose activity increases six-fold 24 h after cells are switched to hypertonic medium. To investigate the mechanism of regulation of the cotransporter by hypertonicity, we used the cDNA encoding the canine Na+-myo-inositol cotransporter that we recently cloned to measure the abundance of the mRNA for the cotransporter and its rate of transcription after changes in osmolality. When MDCK cells were switched from isotonic to hypertonic medium, cotransporter mRNA abundance rose 10-fold in 16 h. Transcription of the cotransporter gene also rose and 16 h after the switch reached a peak ∼15-fold that in isotonic cells. When cells were switched back to isotonic medium, mRNA abundance and transcription of the gene returned to isotonic levels in 8 h and transport rate reached isotonic levels in 48 h. Thus transcription appears to be the primary step in regulation of myo-inositol transport by hypertonicity. -
dc.identifier.bibliographicCitation AMERICAN JOURNAL OF PHYSIOLOGY, v.264, no.1, pp.F20 - F23 -
dc.identifier.issn 0002-9513 -
dc.identifier.scopusid 2-s2.0-0027411405 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/4831 -
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0027411405 -
dc.identifier.wosid A1993KK29200077 -
dc.language 영어 -
dc.publisher American Physiological Society -
dc.title HYPERTONICITY STIMULATES TRANSCRIPTION OF GENE FOR NA+-MYO-INOSITOL COTRANSPORTER IN MDCK CELLS -
dc.type Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -

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