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DC Field | Value | Language |
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dc.citation.endPage | 696 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 689 | - |
dc.citation.title | JOURNAL OF CELLULAR PHYSIOLOGY | - |
dc.citation.volume | 207 | - |
dc.contributor.author | Kim, YH | - |
dc.contributor.author | Song, M | - |
dc.contributor.author | Oh, YS | - |
dc.contributor.author | Heo, K | - |
dc.contributor.author | Choi, JW | - |
dc.contributor.author | Park, JM | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Lim, S | - |
dc.contributor.author | Kwon, H. Moo | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.date.accessioned | 2023-12-22T10:06:27Z | - |
dc.date.available | 2023-12-22T10:06:27Z | - |
dc.date.created | 2014-05-30 | - |
dc.date.issued | 2006-06 | - |
dc.description.abstract | Here we report inhibition of phospholipase C-beta 1 (PLC-beta 1)-mediated signaling by post-translational glycosylation with beta-N-acetylglucosamine (O-GIcNAc modification). In C2C12 myoblasts, isoform-specific knock-down experiments using siRNA showed that activation of bradykinin (BK) receptor led to Stimulation of PLC-beta 1 and subsequent intracellular Ca2+ mobilization. In C2C12 myotubes, O-GlcNAc modification of PLC-beta 1 was markedly enhanced in response to treatment with glucosamine (GIcNH(2)), an inhibitor of O-GIcNAase (PUGNAc) and hyperglycemia. This was associated with more than 50% inhibition of intracellular production of IP3 and Ca2+ mobilization in response to BK. Since the abundance of PLC-beta 1 remained unchanged, these data suggest that O-GIcNAc modification of PLC-PI led to inhibition of its activity. Moreover, glucose uptake stimulated by BK was significantly blunted by treatment with PUGNAc. These data support the notion that O-GIcNAc modification negatively modulates the activity of PLC-beta 1. | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELLULAR PHYSIOLOGY, v.207, no.3, pp.689 - 696 | - |
dc.identifier.doi | 10.1002/jcp.20609 | - |
dc.identifier.issn | 0021-9541 | - |
dc.identifier.scopusid | 2-s2.0-33646344697 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/4821 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33646344697 | - |
dc.identifier.wosid | 000237370200014 | - |
dc.language | 영어 | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Inhibition of phospholipase c-beta 1-mediated signaling by O-GlcNAc modification | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | LINKED N-ACETYLGLUCOSAMINE | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | INDUCED INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | GLUCOSE-UPTAKE | - |
dc.subject.keywordPlus | NEONATAL CARDIOMYOCYTES | - |
dc.subject.keywordPlus | INOSITOL PHOSPHATES | - |
dc.subject.keywordPlus | FEEDBACK-REGULATION | - |
dc.subject.keywordPlus | CYTOSOLIC PROTEINS | - |
dc.subject.keywordPlus | 3T3-L1 ADIPOCYTES | - |
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