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Kang, Joo H.
Translational Multiscale Biofluidics Lab (TMB Lab)
Research Interests
  • Biomedical devices, infectious disease, organ-on-a-chip, microfluidics, mechanobiology

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Tunable SIM: observation at varying spatiotemporal resolutions across the FOV

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Title
Tunable SIM: observation at varying spatiotemporal resolutions across the FOV
Author
Woo, TaeseongJung, Su HyunAhn, CheolwooHwang, ByungjaeKim, HyunggeeKang, Joo H.Park, Jung-Hoon
Issue Date
2020-08
Publisher
OPTICAL SOC AMER
Citation
OPTICA, v.7, no.8, pp.973 - 980
Abstract
To date, imaging systems have generally been designed to provide an even spatiotemporal resolution across the field of view (FOV). However, this becomes a fundamental limitation when we aim to simultaneously observe varying dynamics at different parts of the FOV. In conventional imaging systems, to capture fast dynamics occurring at only a small portion of the FOV, the entire imaging system's sampling rate must be increased. This is a major problem if different parts of the FOV must rather be imaged at high spatial resolutions beyond the diffraction limit and require a sacrifice in temporal resolution. To answer this unmet challenge, we propose tunable SIM, which enables adaptive modulation of spatiotemporally varying structured illumination across different parts of the FOV. Using tunable SIM, we exploit the varying and designable spatiotemporal resolution to demonstrate simultaneous measurements of subdiffraction-limited changes in the actin fine structure of U87MG-EGFP-CD9 cells and the fast viscous flow inducing these structural changes. (c) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
URI
https://scholarworks.unist.ac.kr/handle/201301/48212
URL
https://www.osapublishing.org/optica/fulltext.cfm?uri=optica-7-8-973&id=434285
DOI
10.1364/OPTICA.392800
ISSN
2334-2536
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BME_Journal Papers
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