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Ghim, Cheol-Min
Physical Biology & Biological Physics
Research Interests
  • Control of complex networks, Stochastic fluctuations in a cell, Biochemical information processing, Human microbiome, Ecological inference, Nonequilibrium active system

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Elucidating the role of metal ions in carbonic anhydrase catalysis

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dc.contributor.author Kim, Jin Kyun ko
dc.contributor.author Lee, Cheol ko
dc.contributor.author Lim, Seon Woo ko
dc.contributor.author Andring, Jacob T. ko
dc.contributor.author Adhikari, Aniruddha ko
dc.contributor.author McKenna, Robert ko
dc.contributor.author Ghim, Cheol-Min ko
dc.contributor.author Kim, Chae Un ko
dc.date.available 2020-10-22T08:04:16Z -
dc.date.created 2020-09-23 ko
dc.date.issued 2020-09 ko
dc.identifier.citation NATURE COMMUNICATIONS, v.11, no.1, pp.4557 ko
dc.identifier.issn 2041-1723 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/48187 -
dc.description.abstract Why metalloenzymes often show dramatic changes in their catalytic activity when subjected to chemically similar but non-native metal substitutions is a long-standing puzzle. Here, we report on the catalytic roles of metal ions in a model metalloenzyme system, human carbonic anhydrase II (CA II). Through a comparative study on the intermediate states of the zinc-bound native CA II and non-native metal-substituted CA IIs, we demonstrate that the characteristic metal ion coordination geometries (tetrahedral for Zn2+, tetrahedral to octahedral conversion for Co2+, octahedral for Ni2+, and trigonal bipyramidal for Cu2+) directly modulate the catalytic efficacy. In addition, we reveal that the metal ions have a long-range (~10 Å) electrostatic effect on restructuring water network in the active site. Our study provides evidence that the metal ions in metalloenzymes have a crucial impact on the catalytic mechanism beyond their primary chemical properties. © 2020, The Author(s). ko
dc.language 영어 ko
dc.publisher Nature Publishing Group ko
dc.title Elucidating the role of metal ions in carbonic anhydrase catalysis ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-85090797188 ko
dc.identifier.wosid 000607111200018 ko
dc.type.rims ART ko
dc.identifier.doi 10.1038/s41467-020-18425-5 ko
dc.identifier.url https://www.nature.com/articles/s41467-020-18425-5 ko
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