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Kwon, Hyug Moo
Immunometabolism and Cancer Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorder, Genomic instability


Gene expression profiling in brain following acute systemic hypertonicity: novel genes possibly involved in osmoadaptation

DC Field Value Language Maallem, Said ko Wierinckx, Anne ko Lachuer, Joel ko Kwon, H. Moo ko Tappaz, Marcel L. ko 2014-05-23T05:27:23Z - 2014-05-23 ko 2008-05 ko
dc.identifier.citation JOURNAL OF NEUROCHEMISTRY, v.105, no.4, pp.1198 - 1211 ko
dc.identifier.issn 0022-3042 ko
dc.identifier.uri -
dc.description.abstract In brain osmoprotective genes known to be involved in cellular osmoadaptation to hypertonicity, as well as the related transcription factor tonicity-responsive enhancer binding protein (TonEBP) are only expressed in some cell subsets. In the search for other genes possibly involved in osmoadaptation of brain cells we have analyzed, through microarray, the transcriptional profile of forebrain from rats subjected to 45 min, 90 min, and 6 h systemic hypertonicity. Microarray data were validated by quantitative real-time PCR. Around 23 000 genes gave a reliable hybridization signal. The number of genes showing a higher expression increased from around 15 (45 min) up to nearly 200 (6 h). Among about 30 immediate early genes (IEGs) encoding transcription factors, only Atf3, Verge, and Klf4 showed a rapid increased expression. TonEBP-mRNA tissue level and TonEBP-mRNA labeling in neurons remained unchanged whereas TonEBP labeling was rapidly increased in neurons. Sodium-dependent neutral amino acid transporter-2 (SNAT2) encoded by gene Slc38a2 showed a delayed increased expression. The rapid tonicity-induced activation of Atf3, Verge, and Klf4 may regulate genes involved in osmoadaptation. Nfat5 encoding TonEBP is not an IEG and the early tonicity-induced expression of TonEBP in neurons may result from translational activation. Increased expression of sodium-dependent neutral amino-acid transporter 2 may lead to the cellular accumulation of amino acids for adaptation to hypertonicity. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher WILEY-BLACKWELL ko
dc.title Gene expression profiling in brain following acute systemic hypertonicity: novel genes possibly involved in osmoadaptation ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-41949107014 ko
dc.identifier.wosid 000255286600012 ko
dc.type.rims ART ko
dc.description.wostc 9 *
dc.description.scopustc 10 * 2014-10-18 * 2014-07-12 *
dc.identifier.doi 10.1111/j.1471-4159.2008.05222.x ko
dc.identifier.url ko
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