File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher

권혁무

Kwon, Hyug Moo
Immunometabolism and Cancer Lab.
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Full metadata record

DC Field Value Language
dc.citation.endPage F415 -
dc.citation.number 1 -
dc.citation.startPage F408 -
dc.citation.title AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY -
dc.citation.volume 293 -
dc.contributor.author Jeon, Un Sil -
dc.contributor.author Han, Ki-Hwan -
dc.contributor.author Park, Soo-Hyun -
dc.contributor.author Do Lee, Sang -
dc.contributor.author Sheen, Mee Rie -
dc.contributor.author Jung, Ju-Young -
dc.contributor.author Kim, Wan Young -
dc.contributor.author Sands, Jeff M. -
dc.contributor.author Kim, Jin -
dc.contributor.author Kwon, H. Moo -
dc.date.accessioned 2023-12-22T09:12:50Z -
dc.date.available 2023-12-22T09:12:50Z -
dc.date.created 2014-05-22 -
dc.date.issued 2007-07 -
dc.description.abstract ypokalemia causes a significant decrease in the tonicity of the renal medullary interstitium in association with reduced expression of sodium transporters in the distal tubule. We asked whether hypokalemia caused downregulation of the tonicity-responsive enhancer binding protein (TonEBP) transcriptional activator in the renal medulla due to the reduced tonicity. We found that the abundance of TonEBP decreased significantly in the outer and inner medullas of hypokalemic rats. Underlying mechanisms appeared different in the two regions because the abundance of TonEBP mRNA was lower in the outer medulla but unchanged in the inner medulla. Immunohistochemical examination of TonEBP revealed cell type-specific differences. TonEBP expression decreased dramatically in the outer and inner medullary collecting ducts, thick ascending limbs, and interstitial cells. In the descending and ascending thin limbs, TonEBP abundance decreased modestly. In the outer medulla, TonEBP shifted to the cytoplasm in the descending thin limbs. As expected, transcription of aldose reductase, a target of TonEBP, was decreased since the abundance of mRNA and protein was reduced. Downregulation of TonEBP appeared to have also contributed to reduced expression of aquaporin-2 and UT-A urea transporters in the renal medulla. In cultured cells, expression and activity of TonEBP were not affected by reduced potassium concentrations in the medium. These data support the view that medullary tonicity regulates expression and nuclear distribution of TonEBP in the renal medulla in cell type-specific manners. -
dc.identifier.bibliographicCitation AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v.293, no.1, pp.F408 - F415 -
dc.identifier.doi 10.1152/ajprenal.00502.2006 -
dc.identifier.issn 1931-857X -
dc.identifier.scopusid 2-s2.0-34548039982 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/4702 -
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34548039982 -
dc.identifier.wosid 000247850500051 -
dc.language 영어 -
dc.publisher AMER PHYSIOLOGICAL SOC -
dc.title Downregulation of renal TonEBP in hypokalemic rats -
dc.type Article -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor NKCC2 -
dc.subject.keywordAuthor NCC -
dc.subject.keywordAuthor AQP2 -
dc.subject.keywordAuthor UT-A -
dc.subject.keywordAuthor UT-B -
dc.subject.keywordAuthor hypertonicity -
dc.subject.keywordPlus ENHANCER-BINDING PROTEIN -
dc.subject.keywordPlus LONG-TERM TREATMENT -
dc.subject.keywordPlus DIETARY K-INTAKE -
dc.subject.keywordPlus POTASSIUM-DEPLETION -
dc.subject.keywordPlus COLLECTING DUCT -
dc.subject.keywordPlus STIMULATES TRANSCRIPTION -
dc.subject.keywordPlus UT-A -
dc.subject.keywordPlus TONICITY -
dc.subject.keywordPlus EXPRESSION -
dc.subject.keywordPlus KIDNEY -

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.