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Interrogating Fiber Formation Kinetics with Automated 2D-IR Spectroscopy
- Author(s)
- Strasfeld, David B, Ling, Yun L., Shim, Sang-Hee, Zanni, Martin T.
- Issued Date
- 2008-06-10
- Citation
- Ultrafast Phenomena 16th International Conference, pp.547 - 549
- Abstract
- A new method for collecting 2D-IR spectra that utilizes both a pump-probe beam geometry and a mid-IR pulse shaper is used to gain a fuller understanding of fiber formation in the human islet amyloid polypeptide (hIAPP). We extract structural kinetics in order to better understand aggregation in hIAPP, the protein component of the amyloid fibers found to inhibit insulin production in type II diabetes patients.
- Publisher
- The Optical Society
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