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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 12 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 5 | - |
dc.contributor.author | Sun, Kai | - |
dc.contributor.author | Park, Jiyoung | - |
dc.contributor.author | Gupta, Olga T. | - |
dc.contributor.author | Holland, William L. | - |
dc.contributor.author | Auerbach, Pernille | - |
dc.contributor.author | Zhang, Ningyan | - |
dc.contributor.author | Marangoni, Roberta Goncalves | - |
dc.contributor.author | Nicoloro, Sarah M. | - |
dc.contributor.author | Czech, Michael P. | - |
dc.contributor.author | Varga, John | - |
dc.contributor.author | Ploug, Thorkil | - |
dc.contributor.author | An, Zhiqiang | - |
dc.contributor.author | Scherer, Philipp E. | - |
dc.date.accessioned | 2023-12-22T02:46:57Z | - |
dc.date.available | 2023-12-22T02:46:57Z | - |
dc.date.created | 2014-05-07 | - |
dc.date.issued | 2014-03 | - |
dc.description.abstract | We recently identified endotrophin as an adipokine with potent tumour-promoting effects. However, the direct effects of local accumulation of endotrophin in adipose tissue have not yet been studied. Here we use a doxycycline-inducible adipocyte-specific endotrophin overexpression model to demonstrate that endotrophin plays a pivotal role in shaping a metabolically unfavourable microenvironment in adipose tissue during consumption of a high-fat diet (HFD). Endotrophin serves as a powerful co-stimulator of pathologically relevant pathways within the ‘unhealthy’ adipose tissue milieu, triggering fibrosis and inflammation and ultimately leading to enhanced insulin resistance. We further demonstrate that blocking endotrophin with a neutralizing antibody ameliorates metabolically adverse effects and effectively reverses metabolic dysfunction induced during HFD exposure. Collectively, our findings demonstrate that endotrophin exerts a major influence in adipose tissue, eventually resulting in systemic elevation of pro-inflammatory cytokines and insulin resistance, and the results establish endotrophin as a potential target in the context of metabolism and cancer. | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.5, pp.1 - 12 | - |
dc.identifier.doi | 10.1038/ncomms4485 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.scopusid | 2-s2.0-84921984549 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/4493 | - |
dc.identifier.url | https://www.nature.com/articles/ncomms4485 | - |
dc.identifier.wosid | 000334300800014 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | COLLAGEN-VI | - |
dc.subject.keywordPlus | OBESE MICE | - |
dc.subject.keywordPlus | CHRONIC INFLAMMATION | - |
dc.subject.keywordPlus | TUMOR PROGRESSION | - |
dc.subject.keywordPlus | ADIPOCYTE DEATH | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | HYPOXIA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ENDOCRINE | - |
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