dc.citation.conferencePlace |
KO |
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dc.citation.conferencePlace |
Daegu |
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dc.citation.title |
대한화학회 제116회 학술대회 |
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dc.contributor.author |
Baek, Ho Yong |
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dc.contributor.author |
Lee, Insung |
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dc.contributor.author |
Kim, Yung Sam |
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dc.date.accessioned |
2023-12-19T21:40:34Z |
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dc.date.available |
2023-12-19T21:40:34Z |
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dc.date.created |
2016-01-11 |
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dc.date.issued |
2015-10-16 |
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dc.description.abstract |
Co-solvents strongly influence the solute-solvent interactions of biomolecules in aqueous environment and have profound effects on the stability and activity of several proteins and enzymes. Experimental studies have previously reported on the hydrogen-bond dynamics of water molecules in the presence of co-solvent, but understanding the effect from a solute’s perspective could provide a greater insight towards protein stability. Our study uses 2D IR spectroscopy to investigate how DMSO as a co-solvent affects the dynamics of hydrogen-bonding interactions between the C=O group of ethyl acetate and water by quantitatively estimating the hydrogen-bond exchange rate with and without DMSO in aqueous solution. 2D IR results show spectral signatures of a chemical exchange process; the presence of the co-solvent is found to lower the hydrogen-bond exchange rate by a factor of 5. The measured exchange rates are 6.68×1011 s-1 and 1.48×1011 s-1 in neat water and 1:1 DMSO/water, respectively. The widely different hydrogen-bond lifetimes and exchange rates with and without DMSO indicate a significant change in the ultrafast hydrogen-bond dynamics in the presence of a co-solvent, which in turn might play an important role in the stability and activity of biomolecules. |
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dc.identifier.bibliographicCitation |
대한화학회 제116회 학술대회 |
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dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/41834 |
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dc.language |
영어 |
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dc.publisher |
대한화학회 |
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dc.title |
Co-solvent's Effect on Solute-Solvent Hydrogen-Bond Dynamics: Ultrafast 2D IR Investigations |
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dc.type |
Conference Paper |
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dc.date.conferenceDate |
2015-10-14 |
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