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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 1106 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1095 | - |
dc.citation.title | CELL DEATH AND DIFFERENTIATION | - |
dc.citation.volume | 21 | - |
dc.contributor.author | Shin, H.J. | - |
dc.contributor.author | Kim, H. | - |
dc.contributor.author | Heo, R.W. | - |
dc.contributor.author | Kim, H.J. | - |
dc.contributor.author | Choi, W.S. | - |
dc.contributor.author | Kwon, H. Moo | - |
dc.contributor.author | Roh, G.S. | - |
dc.date.accessioned | 2023-12-22T02:37:23Z | - |
dc.date.available | 2023-12-22T02:37:23Z | - |
dc.date.created | 2014-03-17 | - |
dc.date.issued | 2014-07 | - |
dc.description.abstract | Kainic acid (KA)-induced seizures followed by neuronal death are associated with neuroinflammation and blood-brain barrier (BBB) leakage. Tonicity-responsive enhancer binding protein (TonEBP) is known as a transcriptional factor activating osmoprotective genes, and in brain, it is expressed in neuronal nuclei. Thus dysregulation of TonEBP may be involved in the pathology of KA-induced seizures. Here we used TonEBP heterozygote (+/-) mice to study the roles of TonEBP. Electroencephalographic study showed that TonEBP (+/-) mice reduced seizure frequency and severity compared with wild type during KA-induced status epilepticus. Immunohistochemistry and western blotting analysis showed that KA-induced neuroinflammation and BBB leakage were dramatically reduced in TonEBP (+/-) mice. Similarly, TonEBP-specific siRNA reduced glutamate-induced death in HT22 hippocampal neuronal cells. TonEBP haplodeficiency prevented KA-induced nuclear translocation of NF-κB p65 and attenuated inflammation. Our findings identify TonEBP as a critical regulator of neuroinflammation and BBB leakage in KA-induced seizures, which suggests TonEBP as a good therapeutic target. | - |
dc.identifier.bibliographicCitation | CELL DEATH AND DIFFERENTIATION, v.21, no.7, pp.1095 - 1106 | - |
dc.identifier.doi | 10.1038/cdd.2014.29 | - |
dc.identifier.issn | 1350-9047 | - |
dc.identifier.scopusid | 2-s2.0-84902291471 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/4074 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84902291471 | - |
dc.identifier.wosid | 000337234200007 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Tonicity-responsive enhancer binding protein haplodeficiency attenuates seizure severity and NF-kappa B-mediated neuroinflammation in kainic acid-induced seizures | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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