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김철민

Ghim, Cheol-Min
Physical Biology Biological Physics Lab.
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dc.citation.conferencePlace KO -
dc.citation.title APCTP-ICTP Joint Workshop: Quantitative Life Sciences -
dc.contributor.author Ghim, Cheol-Min -
dc.date.accessioned 2023-12-19T19:38:11Z -
dc.date.available 2023-12-19T19:38:11Z -
dc.date.created 2017-01-17 -
dc.date.issued 2016-11-23 -
dc.description.abstract The single-nucleotide polymorphisms bearing the signatures of balancing selection are enriched in active cis-regulatory regions of immune cells and epithelial cells, the latter of which provide barrier function and innate immunity. Examples associated with ancient trans-specific balancing selection are also discovered. Allelic imbalance in chromatin accessibility and divergence in transcription factor motif sequences indicate that these balanced polymorphisms cause distinct regulatory variation. However, a majority of these variants show no association with the expression level of the target gene. Instead, single-cell experimental data for gene expression and chromatin accessibility demonstrate that heterozygous sequences can lower cell-to-cell variability in proportion to selection strengths. This negative correlation is more pronounced for highly expressed genes and consistently observed when using different data and methods. Based on mathematical modeling, we hypothesize that extrinsic noise from fluctuations in transcription factor activity may be amplified in homozygotes, whereas it is buffered in heterozygotes. While high expression levels are coupled with intrinsic noise reduction, regulatory heterozygosity can contribute to the suppression of extrinsic noise. -
dc.identifier.bibliographicCitation APCTP-ICTP Joint Workshop: Quantitative Life Sciences -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/40561 -
dc.identifier.url https://www.apctp.org/plan.php/apctp-ictp2016/1579 -
dc.language 영어 -
dc.publisher Asia Pacific Center for Theoretical Physics -
dc.title On a Selective Advantage of Heterozygosity in Regulatory Sequences -
dc.type Conference Paper -
dc.date.conferenceDate 2016-11-21 -

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