IUPAC-PSK40 (International Conference on Advanced Polymeric Materials)
Abstract
Cancer is a major cause of mortality globally. Currently, chemotherapy and radiotherapy are used as cancer treatment. Unfortunately, chemotherapy and radiotherapy have negative effect to normal cell. Therefore, targeted delivery of anticancer agents to cancer cell is great challenging. One of drawback is uncertain target which results in cell death. To overcome this problem and enhance imaging for therapy, we focused on imaging mitochondria because mitochondria is crucial to cell function and life. And we develop condensation reaction between CBT and Cystein which is last step of synthesis of D-luciferin inducing self assembly under reduction condition inside cells. We conjugated CBT with Triphenylphosphine (TPP) group which is known as mitochondria targeting moiety. In cancer cell, abundant intracellular glutathione (GSH) will trigger the condensation reaction. Condensation reaction produce hydrophobic oligomer and it form nanoaggregate through self assembly inside cells. Formation of nanoaggregate enhance fluorescence intensity of probe. Owing to TPP, nanostructure will target and image mitochondria. As a results, we develop probe which can selectively target and image mitochondria of cancer cell through intracellular self assembly. It will be useful for cancer therapy.