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차채녕

Cha, Chaenyung
Integrative Biomaterials Engineering Lab.
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Comprehensive examination of mechanical and diffusional effects on cell behavior using a decoupled 3D hydrogel system

Author(s)
Kim, SuntaeSim, Sung BoLee, KangseokCha, Chaenyung
Issued Date
2017-06-02
URI
https://scholarworks.unist.ac.kr/handle/201301/39382
Citation
제18차 한국조직공학 재생의학회 학술대회, pp.59
Abstract
In this study, independent control of mechanical and diffusional properties of hydrogel could be achieved by employing polymeric
crosslinker that allows for the adjustment of the number of crosslinking sites per molecule (degree of substitution). By using the
polymeric crosslinker, with varying degree of substitution, the moduli of the resulting hydrogels could be controlled in a wide
range without changing their concentration. Furthermore, their diffusional properties, as characterized by their swelling ratios, pore
diameters and drug release rates, were not significantly affected by the changes in degree of substitution. The viability of cells
encapsulated in this hydrogel system successfully demonstrated the varying effects of mechanical properties on different cell types,
whereas the cells in a conventional hydrogel system were more significantly influenced by changes in diffusion.
Publisher
한국조직공학 재생의학회

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