(R)-Lipo-Diaza-18-Crown-6 Self-Assembled Monolayer as a Selective Serotonin Receptor

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Title
(R)-Lipo-Diaza-18-Crown-6 Self-Assembled Monolayer as a Selective Serotonin Receptor
Author
Park, Jin-YoungLee, Yoon-SukChang, Byoung-YongKarthikeyan, S.Kim, Kwang S.Kim, Byeang HyeanPark, Su-Moon
Issue Date
2009-05
Publisher
AMER CHEMICAL SOC
Citation
ANALYTICAL CHEMISTRY, v.81, no.10, pp.3843 - 3850
Abstract
A highly selective receptor for serotonin was designed using cages formed by the (R)-lipo-diaza-18-crown-6 self-assembled monolayer (SAM) on gold and experimentally verified by a variety of electrochemical experiments in solutions containing large amounts of dopamine and ascorbic acid, as well as other interferents. The molecular modeling study showed that parameters such as the H-pi interaction provided important driving forces for the cage to form a strong inclusion complex with serotonin. The charge-transfer resistance (R(CT)'s) to/from redox probe ions, Fe(CN)(6)(3-5-), was greatly enhanced because of their electrostatic attractions to ammonium ions of serotonin molecules captured by cages. The changes in R(CT)-values were shown to be remarkably selective for serotonin in the presence of many interferents.
URI
https://scholarworks.unist.ac.kr/handle/201301/3852
URL
https://pubs.acs.org/doi/10.1021/ac900220n
DOI
10.1021/ac900220n
ISSN
0003-2700
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SNS_Journal Papers
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