Enzymatic responsive multifunctional metal organic structure for on command drug release

Abstract

Nanosize controlled MOF has attracted much attention as a drug carrier because it has many pores and huge surface area. However, in studies using MOF as a drug delivery system, the Gatekeeper system for controlled drug release has not been performed much and more research is needed. The existing MOF gate keeper systems also depend on passive targeting for cancer cell targets. Therefore, MOF gate keeper system with active targeting system is needed for more effective cancer drug delivery. In this study, combined treatment of chemo and photodynamic therapy is possible using PDN-224 MOF composed of Zr and porphyrin organic linker. In addition, a MOF gatekeeper system has been developed in which hyaluronic acid is coated by coordination bonds with MOF surface Zr ions. This system enabled active targeting and controlled drug release in response to CD44 and HAdase present in cancer cells. Moreover, the combination therapy improves the cancer therapeutic effect and has the ability to efficiently treat multi-drug resistance cells.