Ni-catalyzed synthesis of 1,5-disubstituted 1,2,3-triazoles
- Author(s)
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김우겸, 홍성유
- Issued Date
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2018-04-19
- URI
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https://scholarworks.unist.ac.kr/handle/201301/37806
- Citation
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대한화학회 제121회 학술발표회
- Abstract
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Regioselective 1,4-disubstituted triazoles have been accessed particularly using copper-catalyze azide-alkyne cycloaddition.[1] In sharp contrast, the synthetic methods to afford 1,5-disubstituted compounds have been developed relatively slowly. Ruthenium- and lanthanide-based catalytic reactions have been practically limited due to the air- and moisture sensitivities. Herein, we unveil nickel-catalyzed highly selective 1,5-disubstituted triazole formation reaction under the ambient conditions.[2] In particular, the reaction protocol is compatible with organic solvent and aqueous solvent conditions, which can be potentially applied to the biochemical approaches.
- Publisher
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대한화학회
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