Enzyme responsive MOF gatekeeper system for combined therapy to increase cancer therapy effect

Abstract

Nanoparticles are interested in cancer treatment. Nanoparticles can load hydrophobic drugs and cancer target ligands can easily be transformed into nanoparticles. Targeting ligand modified nanoparticle can deliver hydrophobic cancer drug to specific cancer cell.These nanoparticles can reduce the side effects of drugs. However, this nanoparticle delivery system has several problems which drug leakage and low drug loading capacity. Here we show HA coated Zr (IV) based porphyrinic metal organic framework (MOF) nanoparticles for controlled drug release and dual cancer therapy systems by enzyme stimuli. Hydrophobic drugs have been loaded into MOF which has large capacity and pore size. In addition, porphyrin-based MOF can be used for photo dynamic treatment. Hyaluronic acid (HA) is easily modified to MOF surface by coordination with Zr ions. HA enhances biocompatibility and imparts cancer targeting capabilities to MOF.