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Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery

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Intra-mitochondrial self-assembly to overcome the intracellular enzymatic degradation ofl-peptides

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Title
Intra-mitochondrial self-assembly to overcome the intracellular enzymatic degradation ofl-peptides
Author
Jeena, M. T.Lee, SeokyoungBarui, Ayan KumarJin, SeongeonCho, YuriHwang, Suk-WonKim, SehoonRyu, Ja-Hyoung
Issue Date
2020-06
Publisher
ROYAL SOC CHEMISTRY
Citation
CHEMICAL COMMUNICATIONS, v.56, no.46, pp.6265 - 6268
Abstract
The design of peptide-based therapeutics is generally based on the replacement ofl-amino acids withd-isomers to obtain improved therapeutic efficiency. However,d-isomers are expensive and frequently induce undesirable immune responses. In the present work, we demonstrate that an intra-mitochondrially self-assembling amphiphilic peptide exhibits analogous activity in bothd- andl-isomeric forms. This outcome is in contrast to the general observation considering higher therapeutic efficiencies ofd-isomers compared withl-analogues. This suggests thatl-peptides overcome proteolytic degradation during intra-mitochondrial self-assembly bothin vitroandin vivo.
URI
https://scholarworks.unist.ac.kr/handle/201301/36793
URL
https://pubs.rsc.org/en/content/articlelanding/2020/CC/D0CC02029J#!divAbstract
DOI
10.1039/d0cc02029j
ISSN
1359-7345
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CHM_Journal Papers
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