File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher

강현욱

Kang, Hyun-Wook
3D Biofabrication Lab.
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

3D 바이오 프린팅 성능이 향상 된 탈세포 조직 기반 바이오 잉크 제작

Alternative Title
Development of a Decellularized Extracellular Matrix based Bio-ink Having an Enhanced 3D Printability
Author(s)
정원우김민경강현욱
Issued Date
2018-05-09
URI
https://scholarworks.unist.ac.kr/handle/201301/36513
Citation
한국정밀공학회 2018년도 춘계학술대회
Abstract
Bio-inks should have proper mechanical properties for precise patterning and cytocompatibility for developing artificial tissues or organs. One of the methods for getting good biological properties is mimicking of biochemical compositions of target tissue. In this aspect, decellularization technique is widely applied to produce a bio-ink. Until now, a decellularized extracellular matrix (dECM) hydrogel form digested by pepsin has been usually applied for bioprinting. Mechanical properties of dECM hydrogel affecting printing performance are affected by various factors. Thus it is hard to control the mechanical properties. Here, we introduce novel method to prepare dECM bio-ink for high printability. A dECM powder was prepared and mixed with a gelatin based bio-ink to be applied to a bioprinting process. Cytocompatibility and patterning tests were conducted to evaluate the performance of developed bio-ink. The results showed that the dECM powder based bio-ink has similar cytocompatibility with traditional dECM hydrogels in terms of the cell viability and proliferation.
Furthermore, two-dimensional (2D) and three-dimensional (3D) patterning results showed that our bio-ink has enhanced
printability compared to traditional dECM hydrogels. These results demonstrate that our method can be applied to develop
various types of dECM based bio-ink having good biocompatibility and printability.
Publisher
한국정밀공학회

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.