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Kang, Sebyung
Protein Nanobio Lab
Research Interests
  • Protein engineering, Drug/diagnostics delivery nanoplatform, Protein-based vaccine delivery systems, Biosensor & imaging


Implementation of P22 Viral Capsids as Nanoplatforms

DC Field Value Language Kang, Sebyung ko Uchida, Masaki ko O'Neil, Alison ko Li, Rui ko Prevelige, Peter E. ko Douglas, Trevor ko 2014-04-10T02:15:46Z - 2013-06-18 ko 2010-10 ko
dc.identifier.citation BIOMACROMOLECULES, v.11, no.10, pp.2804 - 2809 ko
dc.identifier.issn 1525-7797 ko
dc.identifier.uri -
dc.description.abstract Viral capsids are dynamic macromolecular machines which self-assemble and undergo concerted conformational changes during their life cycle. We have taken advantage of the inherent structural flexibility of viral capsids and generated two morphologically different types of viral nanoplatforms from the bacteriophage P22 capsids. Their interior surfaces were genetically manipulated For site-specific attachment of 0 biotin linker. The extent of internal modifications in each capsid form was Characterized by high-resolution mass spectrometry and the analyses revealed that the reactivity of the genetically introduced residues located on the internal surface changes according to the structural transformation of the capsid. Internally modified capsids having 10 nm diameter pores at the 12 icosahedral vertices, so-called wiffle-balls (WB), exhibited the capability to entrap the large tetrameric protein complex streptavidin via the biotin linker anchored onto the interior surface of the WB. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher AMER CHEMICAL SOC ko
dc.title Implementation of P22 Viral Capsids as Nanoplatforms ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-77957884425 ko
dc.identifier.wosid 000282840200034 ko
dc.type.rims ART ko
dc.description.scopustc 27 * 2014-07-12 *
dc.identifier.doi 10.1021/bm100877q ko
dc.identifier.url ko
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