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Kim, Kyoung Taek
KT Kim Group at UNIST
Research Interests
  • Polymer Chemistry
  • Organic Chemistry
  • Supramolecular Chemistry
  • Biopolymers

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Glucose-Responsive Disassembly of Polymersomes of Sequence-Specific Boroxole-Containing Block Copolymers under Physiologically Relevant Conditions

DC Field Value Language
dc.contributor.author Kim, Hyunkyu ko
dc.contributor.author Kong, Young Ji ko
dc.contributor.author Jeong, Eun Sun ko
dc.contributor.author Kang, Sebyung ko
dc.contributor.author Kim, Kyoung Taek ko
dc.date.available 2014-04-10T02:14:56Z -
dc.date.created 2013-07-09 ko
dc.date.issued 2012-10 ko
dc.identifier.citation ACS MACRO LETTERS, v.1, no.10, pp.1194 - 1198 ko
dc.identifier.issn 2161-1653 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/3573 -
dc.description.abstract Polymers containing organoboronic acids have recently gained interest as sugar-responsive materials owing to the reversible binding of saccharides to boronic acids, which triggers a change in the physical and chemical properties of these polymers, such as their water solubility. In particular, the ability of these polymers to bind glucose has attracted considerable attention because of the promise of these materials for the development of sensors and drug delivery systems for glucose-related human diseases, such as diabetes. We report here a new class of sugar-responsive polymers that are based on a sequence-specific copolymer of styreneboroxole and N-functionalized maleimide. The reversible addition-fragmentation and chain transfer (RAFT) polymerization of this pair of monomers ensured that a glucose receptor alternates with a nonresponsive solubilizing group throughout the sugar-responsive polymer chain. Due to the presence of hydrophilic solubilizing groups beween the solubility-switching boroxole moieties in the membrane-forming block, the polymersomes of the block copolymers responded to a lower level of glucose in the medium, resulting in diassembly of the bilayer membrane under a physiologically relevant pH and glucose level. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher AMER CHEMICAL SOC ko
dc.title Glucose-Responsive Disassembly of Polymersomes of Sequence-Specific Boroxole-Containing Block Copolymers under Physiologically Relevant Conditions ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84886235399 ko
dc.identifier.wosid 000309804800010 ko
dc.type.rims ART ko
dc.identifier.doi 10.1021/mz3004192 ko
dc.identifier.url http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=20&SID=Y2PVknxoxMhoJXBWHvD&page=1&doc=1 ko
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