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Cho, Yoon-Kyoung
FRUITS Lab.
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SINGLE CELL ANALYSIS ON THE ROLE OF TGF-β1 IN AUTOPHAGY OF TUMOR CELL-INTERACTED STROMA FIBROBLASTS

Author(s)
Kim, JunyoungKarakas, Hacer EzgiGozuacik, DevrimCho, Yoon-Kyoung
Issued Date
2015-10-27
URI
https://scholarworks.unist.ac.kr/handle/201301/35461
Citation
19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015, pp.358 - 360
Abstract
The communication between carcinoma associated fibroblast cells (CAFs) and tumor cells and autophagy activation mechanism during this interaction are important in the survival, proliferation and metastasis of cancer. Here we introduce a single cell-based screening platform consisted of PDMS porous membrane. In this paper, single cell-based screening platform is used (1) to trap single tumor cells by using gravitation force and agitation, (2) to monitor the autophagy of fibroblasts after interaction, and (3) to study paracrine factors from the heterogenic tumor cells inducing autophagy activation in fibroblasts. Our study highlights the role of TGF-β1 secreted by tumor cells in the autophagy activation in fibroblast using a novel screening system.
Publisher
Chemical and Biological Microsystems Society

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