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Choi, Kyoung Jin
Energy Conversion Materials (EcoMAT) Lab
Research Interests
  • Solar cells, thermoelectrics, piezoelectric


N,N,N-Trimethyl chitosan nanoparticles for controlled intranasal delivery of HBV surface antigen

DC Field Value Language Subbiah, Ramesh ko Ramalingam, Prakash ko Ramasundaram, Subramaniyan ko Kim, Do Yang ko Park, Kwideok ko Ramasamy, Mohan K. ko Choi, Kyoung Jin ko 2014-04-10T01:57:58Z - 2013-06-19 ko 2012-08 -
dc.identifier.citation CARBOHYDRATE POLYMERS, v.89, no.4, pp.1289 - 1297 ko
dc.identifier.issn 0144-8617 ko
dc.identifier.uri -
dc.identifier.uri ko
dc.description.abstract Hepatitis B virus surface antigen (HBsAg) loaded N,N,N-trimethyl chitosan nanoparticles (N-TMC NPs) were formulated and studied for controlled intranasal delivery. The size and surface properties of the NPs can be tuned by modifying the concentration of N-TMC and found to be 66 +/- 13, 76 +/- 9 nm for 0.25 and 0.5 wt.% respectively. Loading of 380 and 760 ill of HBsAg yielded 143 +/- 33, 259 +/- 47 nm sized spherical N-TMC NPs with highest loading efficiency and capacity of 90-93%, and 96-97% respectively. In vitro drug release analysis ensured 93% cumulative release of HBsAg antigen over prolonged period (43 days). In vivo immunological study was performed using 6-8 weeks old female BALB mice and reveals adjuvants efficiency of NPs for antigen is highly stable and better than standard. Obtained results show that N-TMC NPs can be extensively used in controlled intra nasal delivery to treat various diseases including hepatitis B and allergic rhinitis. ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.publisher ELSEVIER SCI LTD ko
dc.subject Allergic rhinitis ko
dc.subject Chitosan nanoparticles ko
dc.subject Hepatitis B ko
dc.subject Hepatitis b virus surface antigens ko
dc.subject In-vitro ko
dc.subject In-vivo ko
dc.subject Intranasal ko
dc.subject Loading efficiency ko
dc.subject Nasal delivery ko
dc.subject Surface antigen ko
dc.subject Trimethyl chitosan ko
dc.title N,N,N-Trimethyl chitosan nanoparticles for controlled intranasal delivery of HBV surface antigen ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84861602931 ko
dc.identifier.wosid 000305593900040 ko
dc.type.rims ART ko
dc.description.scopustc 3 * 2014-07-12 *
dc.identifier.doi 10.1016/j.carbpol.2012.04.056 ko
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