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Suh, Pann-Ghill
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The function of PLCγ1 in developing mouse mDA system

Author(s)
Kang, Du-SeockKim, Il ShinBaik, Ja-HyunKim, DaesooCocco, LucioSuh, Pann-Ghill
Issued Date
2020-01
DOI
10.1016/j.jbior.2019.100654
URI
https://scholarworks.unist.ac.kr/handle/201301/33037
Fulltext
https://www.sciencedirect.com/science/article/pii/S2212492619300752?via%3Dihub
Citation
ADVANCES IN BIOLOGICAL REGULATION, v.75, pp.100654
Abstract
During neural development, growing neuronal cells consistently sense and communicate with their surroundings through the use of signaling molecules. In this process, spatiotemporally well-coordinated intracellular signaling is a prerequisite for proper neuronal network formation. Thus, intense interest has focused on investigating the signaling mechanisms in neuronal structure formation that link the activation of receptors to the control of cell shape and motility. Recent studies suggest that Phospholipase C gamma1 (PLCγ1), a signal transducer, plays key roles in nervous system development by mediating specific ligand-receptor systems. In this overview of the most recent advances in the field, we discuss the mechanisms by which extracellular stimuli trigger PLCγ1 signaling and, the role PLCγ1 in nervous system development.
Publisher
Elsevier Ltd
ISSN
2212-4926
Keyword (Author)
Axon guidanceCalcium signalingCytoskeletonPLCG1

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