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Cho, Yoon-Kyoung
Integrated Nano-Biotech Lab (INBL)
Research Interests
  • Microfluidics, Lab-on-a-chip, personalized biomedical diagnostics, nanobioengineering

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A fidget spinner for the point-of-care diagnosis of urinary tract infection

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Title
A fidget spinner for the point-of-care diagnosis of urinary tract infection
Author
Michael, IssacKim, DongyoungGulenko, OleksandraKumar, SumitKumar, SaravanaClara, JothiKi, Dong YeobPark, JuheeJeong, Hyun YongKim, Taek SooKwon, SunghoonCho, Yoon-Kyoung
Issue Date
2020-06
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE BIOMEDICAL ENGINEERING, v.4, no.6, pp.591 - 600
Abstract
The point-of-care detection of pathogens in biological samples in resource-limited settings should be inexpensive, rapid, portable, simple and accurate. Here, we describe a custom-made fidget spinner that rapidly concentrates pathogens in 1-ml samples of undiluted urine by more than 100-fold for the on-device colorimetric detection of bacterial load and pathogen identification. In Tiruchirappalli, India, the device enabled the on-site detection of infection with the naked eye within 50 min in urine samples from 39 patients suspected of having a urinary tract infection. We also show that, in 30 clinical samples of urinary tract infection, the device can be used to perform an antimicrobial susceptibility test for the antimicrobial drugs ciprofloxacin and cefazolin within 120 min. The fidget spinner could be used in low-resource settings as an inexpensive handheld point-of-care device for the rapid concentration and detection of pathogens in urine samples. A custom-made fidget spinner rapidly concentrates pathogens in 1-ml samples of undiluted urine by more than 100-fold for the on-device colorimetric detection of bacterial load and pathogen identification.
URI
https://scholarworks.unist.ac.kr/handle/201301/33004
URL
https://www.nature.com/articles/s41551-020-0557-2
DOI
10.1038/s41551-020-0557-2
ISSN
2157-846X
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BME_Journal Papers
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