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Lim, Chunghun
Neurogenetics & Ribonomics Laboratory (The Lim Lab)
Research Interests
  • Ribosome Biology, Translation, Neurodegeneration, Behavioral Genetics

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ATAXIN-2 activates PERIOD translation to sustain circadian rhythms in Drosophila

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Title
ATAXIN-2 activates PERIOD translation to sustain circadian rhythms in Drosophila
Author
Lim, ChunghunAllada, Ravi
Issue Date
2013-05
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Citation
SCIENCE, v.340, no.6134, pp.875 - 879
Abstract
Evidence for transcriptional feedback in circadian timekeeping is abundant, yet little is known about the mechanisms underlying translational control. We found that ATAXIN-2 (ATX2), an RNA-associated protein involved in neurodegenerative disease, is a translational activator of the rate-limiting clock component PERIOD (PER) in Drosophila. ATX2 specifically interacted with TWENTY-FOUR (TYF), an activator of PER translation. RNA interference-mediated depletion of Atx2 or the expression of a mutant ATX2 protein that does not associate with polyadenylate-binding protein (PABP) suppressed behavioral rhythms and decreased abundance of PER. Although ATX2 can repress translation, depletion of Atx2 from Drosophila S2 cells inhibited translational activation by RNA-tethered TYF and disrupted the association between TYF and PABP. Thus, ATX2 coordinates an active translation complex important for PER expression and circadian rhythms.
URI
https://scholarworks.unist.ac.kr/handle/201301/3277
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84877741071
DOI
10.1126/science.1234785
ISSN
0036-8075
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