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- Hong, Sung You
- Synthetic Organic Chemistry Lab.
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Synthesis of 18F-Labeled Aryl Fluorosulfates via Nucleophilic Radiofluorination
- Author(s)
- Kwon, Young-Do, Jeon, Min Ho, Park, Nam Kyu, Seo, Jeong Kon, Son, Jeongmin, Ryu, Young Hoon, Hong, Sung You, Chun, Joong-Hyun
- Issued Date
- 2020-07
- Citation
- ORGANIC LETTERS, v.22, no.14, pp.5511 - 5516
- Abstract
- Sulfuryl fluoride gas is a key reagent for SO2F transfer. However, conventional SO2F transfer reactions have limited F-18-radiochemistry translation, due to the inaccessibility of gaseous [F-18] SO2F2. Herein, we report the first SO2F2-free synthesis of aryl [F-18]fluorosulfates from both phenolic and isolated aryl imidazylate precursors with cyclotron-produced F-18(-) . The radiochemical yields ranged from moderate to good with excellent functional group tolerance. The reliability of our approach was validated by the automated radiosynthesis of 4-acetamidophenyl [F-18]fluorosulfate.
- Publisher
- AMER CHEMICAL SOC
- ISSN
- 1523-7060
- Keyword
- SUFEX CLICK CHEMISTRY, FLUORIDE, F-18, RADIOCHEMISTRY, DERIVATIVES, REACTIVITY, REAGENT
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